摘要
目的检测分析宫颈癌前病变及宫颈癌人乳头状瘤病毒(HPV)感染类型。方法回顾性选取2020年2月—2022年6月本院HPV感染检测患者2042例,依据检测结果分为宫颈癌组(1164例)、宫颈癌前病变组(444例)、宫颈细胞学正常组(434例)3组。统计分析3组一般资料、HPV感染类型,并统计分析3组不同年龄、民族患者的HPV感染情况,分析3组主要感染类型分布情况,统计分析宫颈癌组不同病理特征患者的HPV感染类型。结果宫颈癌组患者年龄≤35岁比率低于宫颈癌前病变组、宫颈细胞学正常组,>35岁比率高于宫颈癌前病变组、宫颈细胞学正常组(P<0.05)。宫颈癌组、宫颈癌前病变组患者的HPV感染率均高于宫颈细胞学正常组(P<0.05),其中宫颈癌组患者的HPV多重感染率低于宫颈癌前病变组(P<0.05),高于宫颈细胞学正常组(P<0.05)。宫颈癌组年龄>35岁患者的HPV感染率高于≤35岁患者(P<0.05),宫颈细胞学正常组年龄>35岁患者的HPV感染率低于≤35岁患者(P<0.05)。宫颈癌组患者的主要感染类型为HPV16、HPV18、HPV58、HPV52、HPV33,宫颈癌前病变组患者的主要感染类型为HPV16、HPV58、HPV33、HPV52,宫颈细胞学正常组患者的主要感染类型为HPV16、HPV58、HPV18、HPV52。宫颈癌组鳞状细胞癌患者的HPV感染率高于非鳞状细胞癌患者(P<0.05),其中高分化患者的单一感染率低于低分化、中分化患者,多重感染率高于低分化、中分化患者(P<0.05)。结论宫颈癌HPV感染率高于宫颈癌前病变,类型主要为多重感染。
Objective This paper aims to investigate and analyze the types of cervical precancerous lesions and human papillomavirus(HPV)infection.Methods From February 2020 to June 2022,2042 patients with HPV infection in our hospital were retrospectively selected and divided into cervical cancer group(1164 cases),cervical precancerous lesions group(444 cases),and the cervical cytology normal group(434 cases)according to the test results.The general data and HPV infection types of the three groups were statistically analyzed;the HPV infection status of the three groups of patients with different ages and ethnicities,the distribution of the main infection types of the three groups,and the HPV infection types of patients with different pathological characteristics of the cervical cancer group were statistically analyzed.Results The proportion of patients aged≤35 in the cervical cancer group was lower than that in the cervical precancerous lesion group and the normal cervical cytology group,and the proportion of those>35 years old was higher than that in the cervical precancerous lesion group and the normal cervical cytology group(P<0.05).The HPV infection rates of cervical cancer group and cervical precancerous lesion group were higher than normal cervical cytology group(P<0.05).The multiple infection rate of HPV in cervical cancer group was lower than that in cervical precancerous lesion group(P<0.05),and higher than that in cervical cytology normal group(P<0.05).The HPV infection rate of patients aged>35 in cervical cancer group was higher than that of patients aged≤35(P<0.05),and the HPV infection rate of patients aged>35 in normal cervical cytology group was lower than that of patients aged≤35(P<0.05).The main infection types of patients in the cervical cancer group were HPV16,HPV18,HPV58,HPV52,and HPV33;the main infection types of patients with cervical precancerous lesions were HPV16,HPV58,HPV33,and HPV52;the main infection types of patients in the cervical cytology group were HPV16,HPV58,HPV18,HPV52.The HPV infec
作者
李晓娟
LI Xiao-juan(Xinxiang Maternal and Child Health Care Hospital,Henan 453000,China)
出处
《中国卫生检验杂志》
CAS
2023年第7期853-857,共5页
Chinese Journal of Health Laboratory Technology
关键词
宫颈癌前病变
宫颈癌
人乳头状瘤病毒
感染类型
病理特征
Cervical precancerous lesions
Cervical cancer
Human papllomavirus
Infection type
Pathological features
