摘要
目的 探讨谷氨酰胺联合序贯肠内营养治疗对重症脑梗死患者营养状态与预后的影响。方法 随机选取2020年6月—2021年12月曲阜市人民医院收治的重症脑梗死患者80例为研究对象,以随机数表法分为对照组(40例,序贯肠内营养支持治疗)、观察组(40例,谷氨酰胺联合序贯肠内营养治疗),对比两组治疗前后前白蛋白(PAB)、白蛋白(ALB)、血红蛋白(Hb)水平评估营养状态,并比较两组免疫球蛋白IgA、IgM、IgG水平评估免疫功能,统计两组胃肠道与感染相关并发症发生率。结果 观察组治疗后PAB、ALB、Hb分别为(221.51±9.15)mg/L、(35.51±3.27)g/L、(136.15±11.19)g/L,均高于对照组,差异有统计学意义(t=4.561、3.419、3.244,P<0.05);观察组治疗后IgA、IgM、IgG分别为(2.02±0.34)g/L、(1.22±0.21)g/L、(13.62±2.15)g/L,均高于对照组,差异有统计学意义(t=4.064、3.708、4.218,P<0.05);观察组胃肠道与感染相关并发症发生率分别为7.50%、5.00%,均低于对照组25.00%、22.50%,差异有统计学意义(χ^(2)=4.501、5.165,P<0.05)。结论 对重症脑梗死者在序贯肠内营养治疗同时联用谷氨酰胺干预可改善患者营养状态及免疫功能,且可降低患者并发症风险。
Objective To explore the role of sequential enteral nutrition therapy combined with glutamine intervention in improving the nutritional status and prognosis of patients with severe cerebral infarction.Methods A total of 80 patients with severe cerebral infarction admitted to Qufu People's Hospital from June 2020 to December 2021 were random selected.They were divided into a control group(n=40,sequential enteral nutrition support treatment)and an observation group(n=40,glutamine combined with sequential enteral nutrition support treatment)using a random number table method.The levels of prealbumin(PAB),albumin(ALB)and hemoglobin(Hb)were compared between the two groups before and after treatment to evaluate the nutritional status.The levels of IgA,IgM and IgG were compared between the two groups to evaluate the immune function.The incidence of gastrointestinal and infection-related complications in the two groups was counted.Results After treatment,PAB,ALB,and Hb in the observation group were(221.51±9.15)mg/L,(35.51±3.27)g/L,and(136.15±11.19)g/L,respectively,which were higher than those in the control group,and the difference was statistically significant(t=4.561,3.419,3.244,P<0.05).After treatment,IgA,IgM,and IgG in the observation group were(2.02±0.34)g/L,(1.22±0.21)g/L,and(13.62±2.15)g/L,respectively,which were higher than those in the control group,and the difference was statistically significant(t=4.064,3.708,4.218,P<0.05).The incidences of gastrointestinal and infection-related complications in the observation group were 7.50%and 5.00%,respectively,which were lower than those in the control group(25.00%and 22.50%),with statistically significant differences(χ^(2)=4.501,5.165,P<0.05).Conclusion For patients with severe cerebral infarction,sequential enteral nutrition therapy combined with glutamine intervention can improve the nutritional status and immune function of patients,and can reduce the risk of complications in patients.
作者
袁洪飞
YUAN Hongfei(Department of Critical Care Medicine,Qufu People's Hospital,Qufu,Shandong Province,273100 China)
出处
《中外医疗》
2023年第5期24-28,共5页
China & Foreign Medical Treatment
关键词
重症脑梗死
谷氨酰胺
序贯肠内营养
营养状态
免疫功能
并发症
Severe cerebral infarction
Glutamine
Sequential enteral nutrition
Nutritional status
Immune function
Complications
