摘要
研究千里香的化学成分。采用硅胶、ODS、Sephadex LH-20、制备液相等多种色谱分离技术进行分离纯化,通过波谱数据分析进行结构鉴定。从千里香70%乙醇提取物中分离得到26个化合物,分别鉴定为千里香脂素(1)、8-去甲基川陈皮素(2)、ficusal(3)、lariciresinol-4′-monomethy ether(4)、(±)-5′-methoxy-4′-O-methyllariciresinol(5)、diospyrosin(6)、(-)-9′-O-E-feruloyl-lyoniresinol(7)、7-O-methylphellodenol-B(8)、欧芹烯酮酚甲醚(9)、3,4′-二羟基-3′,5′-二甲氧基苯丙酮(10)、4′-羟基-5,7-二甲氧基二氢黄酮(11)、5-羟基-6,7,3′,4′-四甲氧基二氢黄酮(12)、4′-羟基-5,7,3′-三甲氧基二氢黄酮(13)、5,7,3′,4′,5′-五甲氧基二氢黄酮(14)、2′,4-二羟基-3′,4′,6′-三甲氧基查尔酮(15)、2′,3-二羟基-4,4′,6′-三甲氧基查尔酮(16)、楝叶吴萸素B(17)、2′-羟基-3,4,5,4′,6′-五甲氧基查尔酮(18)、2′-羟基-3,4,4′,6′-四甲氧基查尔酮(19)、5,8-二羟基-6,7,3′,4′-四甲氧基黄酮(20)、3′-羟基-5,6,7,8,4′,5′-六甲氧基黄酮(21)、5,3′,5′-三羟基-7,4′-二甲氧基黄酮(22)、5,7,3′-三羟基-8,4′-二甲氧基黄酮(23)、3′-羟基-5,6,7,4′-四甲氧基黄酮(24)、5,7,3′,4′,5′-五甲氧基黄酮(25)、5-羟基-6,7,8,3′,4′-五甲氧基黄酮(26),其中化合物1、2为新化合物,化合物3~8、10~13、15、16、20~24为首次从九里香属植物中分离得到,化合物17为首次从千里香中分离得到。
To study the chemical constituents of Murraya paniculata(L.)Jack,two new compounds,named as murrayanin(1)and 8-demethylnobiletin(2),along with twenty-four known compounds(3-26)were isolated from the 70%EtOH extract of M.paniculata by various chromatographic techniques such as silica gel,ODS,Sephadex-LH 20,Pre-HPLC,their structures was elucidated by spectral data analysis.The known compounds were identified as ficusal(3),lariciresinol-4′-monomethy ether(4),(±)-5′-methoxy-4′-O-methyllariciresinol(5),diospyrosin(6),(-)-9′-O-E-feruloyl-lyoniresinol(7),7-O-methylphellodenol-B(8),osthenon(9),3,4′-dihydroxy-3′,5′-dimethoxyphenylacetone(10),4′-hydroxy-5,7-dimethoxyflavanone(11),cystosiphonin(12),4′-hydroxy-5,7,3′-trimethoxyflavanone(13),5,7,3′,4′,5′-pentamethoxyflavanone(14),2′,4-dihydroxy-3′,4′,6′-trimethoxychalcone(15),2′,3-dihydroxy-4,4′,6′-trimethoxychalcone(16),evofolin B(17),2′-hydroxy-3,4,5,4′,6′-pentamoxychalcone(18),2′-hydroxy-3,4,4′,6′-tetramethoxychalone(19),5,8-dihydroxy-6,7,3′,4′-tetramethoxyflavone(20),3′-hydroxy-5,6,7,8,4′,5′-hexamethoxyflavone(21),5,3′,5′-trihydroxy-7,4′-dimethoxyflavone(22),5,7,3′-trihydroxy-8,4′-dimethoxyflavone(23),8-hydroxy-5,6,7,3′,4′-pentamoxyflavone(23),3′-hydroxy-5,6,7,4′-tetramethoxyflavone(24),5,7,3′,4′,5′-pentamethoxyflavone(25)and 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone(26),respectively.Compounds 3-8,10-13,15,16,20-24 were obtained from the genus Murraya for the first time,and compound 17 were isolated from M.paniculata for the first time.
作者
王茹茹
张珊珊
许红涛
王永丽
侴桂新
WANG Ru-ru;ZHANG Shan-shan;XU Hong-tao;WANG Yong-li;CHOU Gui-xin(Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《天然产物研究与开发》
CAS
CSCD
2023年第5期787-797,共11页
Natural Product Research and Development
基金
重大新药创制科技重大专项子课题(2019ZX09735002-004)。
关键词
千里香
化学成分
木脂素
黄酮
香豆素
Murraya paniculata(L.)Jack.
chemical constituent
lignan
flavone
coumarin
