摘要
目的探讨血清多不饱和脂肪酸(PUFA)与脑梗死患者总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及预后的关系。方法回顾性分析2020年2月至2021年2月青岛市城阳区人民医院收治的100例脑梗死患者临床资料,根据患者预后情况进行分组,分为预后良好组(n=51)与预后不良组(n=49)。比较两组一般资料,检测并对比两组患者血清PUFA、总胆固醇、甘油三酯、LDL-C及HDL-C水平变化;采用Pearson相关性分析分析脑梗死患者血清PUFA与总胆固醇、甘油三酯、LDL-C及HDL-C水平的相关性;分析血清PUFA评估脑梗死患者预后不良的价值。结果预后不良组年龄、体重指数分别为(65.27±7.89)岁、(25.09±2.21)km/m^(2),均大于预后良好组[(58.21±8.29)岁、(23.15±2.01)km/m^(2)],差异均有统计学意义(P<0.05)。预后不良组血清总胆固醇、甘油三酯、LDL-C水平分别为(4.48±0.71)、(1.49±0.29)、(2.69±0.62)mmol/L,均高于预后良好组[(3.41±0.72)、(1.26±0.32)、(1.91±0.47)mmol/L],血清HDL-C、PUFA水平分别为(1.24±0.20)mmol/L、(34.61±4.81)%,均低于预后良好组[(1.47±0.31)mmol/L、(39.41±4.20)%],差异均有统计学意义(P<0.05)。经过受试者工作特征(ROC)曲线分析证实,血清PUFA可用于脑梗死患者预后不良的评估,曲线下面积为0.775。将100例脑梗死患者按PUFA水平不同进行分组,分为PUFA≥36.37%(n=58)及PUFA<36.37%(n=42),PUFA≥36.37%组血清总胆固醇、甘油三酯、LDL-C明显低于PUFA<36.37%组,HDL-C水平高于PUFA<36.37%组,差异均有统计学意义(P<0.05)。经Pearson相关性分析结果显示,总胆固醇、甘油三酯、LDL-C水平与血清PUFA水平呈负相关(P<0.05),HDL-C与血清PUFA水平呈正相关(P<0.05)。结论脑梗死患者中血清PUFA水平降低,与患者总胆固醇、甘油三酯、LDL-C水平呈负相关,与HDL-C水平呈正相关,且可预测患者预后情况。
Objective To investigate the relationship between serum polyunsaturated fatty acid(PUFA),total cholesterol,triglyceride,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and prognosis in patients with cerebral infarction.Methods The clinical data of 100 patients with cerebral infarction treated in Qingdao Chengyang District People's Hospital from February 2020 to February 2021 were retrospectively analyzed.According to the prognosis of the patients,they were divided into good prognosis group(n=51)and bad prognosis group(n=49).The basic data of the two groups were compared,and the changes of PUFA,total cholesterol,triglyceride,LDL-C and HDL-C levels of the two groups were detected and compared.Pearson correlation analysis was used to analyzed the patients with cerebral infarction.Results The age and body mass index of the poor prognosis group were(65.27±7.89)years old and(25.09±2.21)km/m^(2),which were significantly higher than those of the good prognosis group[(58.21±8.29)years old and(23.15±2.01)km/m^(2)],the differences were statistically significant(P<0.05).The levels of serum total cholesterol,triglyceride and LDL-C in the poor prognosis group were(4.48±0.71),(1.49±0.29),(2.69±0.62)mmol/L,respectively,which were higher than those in the good prognosis group[(3.41±0.72),(1.26±0.32),(1.91±0.47)mmol/L],and the levels of serum HDL-C and PUFA were(1.24±0.20)mmol/L,(34.61±4.81)%,which were lower than those in the good prognosis group[(1.47±0.31)mmol/L,(39.41±4.20)%],the differences were statistically significant(P<0.05).Receiver operating characteristic(ROC)analysis confirmed that serum PUFA could be used to evaluate the poor prognosis of patients with cerebral infarction,and the area under the curve was 0.775.One hundred patients with cerebral infarction were divided into PUFA≥36.37%(n=58)and PUFA<36.37%(n=42)according to different PUFA levels.Serum total cholesterol,triglyceride and LDL-C levels in PUFA≥36.37%group were significantly lower than those in PUFA<3
作者
袁蕾
苗芳元
张梦琳
徐建军
YUAN Lei;MIAO Fang-yuan;ZHANG Meng-lin(Department of Neurology,Qingdao Chengyang District People's Hospital,Qingdao Shandong 266109,China;Department of Traumatic Orthopedics,Qingdao Chengyang District People's Hospital,Qingdao Shandong 266109,China;Department of Gastroenterology,Qingdao Chengyang District People's Hospital,Qingdao Shandong 266109,China)
出处
《临床和实验医学杂志》
2023年第7期685-689,共5页
Journal of Clinical and Experimental Medicine
基金
山东省医药卫生科技发展计划项目(编号:2016WS0290)。
关键词
多不饱和脂肪酸
脑梗死
总胆固醇
甘油三酯
Polyunsaturated fatty acids
Cerebral infarction
Total cholesterol
Triglyceride
