摘要
目的研究抗心磷脂抗体(ACA)及抗β2糖蛋白1抗体(anti-β2-GP1)在脑梗死患者中的表达及其临床意义。方法选取确诊的脑梗死患者211例,按照是否合并高脂血症,分为血脂正常脑梗死组(n=121)和高脂血症合并脑梗死组(n=90)。采用酶联免疫吸附测定(ELISA)对两组患者血清IgA、IgG、IgM型ACA和anti-β2-GP1进行测定并比较两组阳性率的差异;同时比较不同年龄、性别、病灶数量的血脂正常脑梗死组患者ACA和anti-β2-GP1阳性率差异及脑梗死患者两类抗体之间的相关性。结果血脂正常脑梗死组和高脂血症合并脑梗死组的ACA阳性率分别为14.0%和4.4%(χ~2=4.295,P=0.038),anti-β2-GP1阳性率分别为17.4%和5.6%(χ~2=6.651,P=0.010)。血脂正常脑梗死组患者中,90例单发性脑梗死和31例多发性脑梗死患者的ACA阳性率分别为8.9%和29.0%(χ~2=7.748,P=0.005),anti-β2-GP1阳性率分别为10.0%和38.7%(χ~2=13.250,P=0.000);在血脂正常脑梗死组患者中,≤50岁67例,>50岁54例,ACA阳性率分别为20.9%和5.6%(χ~2=4.626,P=0.031),anti-β2-GP1阳性率分别为25.4%和7.4%(χ~2=5.534,P=0.019);ACA和anti-β2-GP1阳性率在性别上差异无统计学意义(P>0.05);一致性χ~2检验显示211例脑梗死患者ACA和anti-β2-GP1有相关性(P<0.05)。结论 ACA及anti-β2-GP1可能是血脂正常中青年脑梗死患者的重要发病原因之一,临床应加强对这类人群ACA及anti-β2-GP1的联合检测。
Objective To study the expression and clinical significance of anti cardiolipin antibody(ACA)and anti beta 2 glycoprotein 1 antibody(anti-β2-GP1)in cerebral infarction without hyperlipidemia group.Methods A total of 211 patients with cerebral infarction were selected and divided into two groups according to whether they were hyperlipidemia:cerebral infarction without hyperlipidemia group and hyperlipidemia combined cerebral infarction group.The serum levels of IgA,IgG,IgM type ACA and anti-β2-GP1 were measured by enzyme linked immunosorbent assay(ELISA),the positive rates of the two groups were compared.The positive rates of ACA and anti-β2-GP1 in patients with cerebral infarction with different ages,genders and number of lesions were compared,the correlation between the two types of antibodies in patients with cerebral infarction were analyzed.Results There were 121 cases of cerebral infarction without hyperlipidemia group,90 cases of cerebral infarction with hyperlipidemia group.The positive rates of ACA were 14.0%and 4.4%(χ^2=4.295,P=0.038),respectively.The positive rates of anti-β2-GP1 were 17.4%and 5.6%(χ^2=6.651,P=0.010),respectively.The positive rates of ACA and anti-β2-GP1 in the two groups were statistically difference.Among the patients of cerebral infarction without hyperlipidemia group,90 cases were single cerebral infarction and 31 cases were multiple cerebral infarction.The positive rates of ACA were 8.9%and 29.0%(χ^2=7.748,P=0.005),respectively.The positive rates of anti-β2-GP1 were 10.0%and 38.7%(χ^2=13.250,P=0.000),respectively.In the patients in cerebral infarction without hyperlipidemia group,67 cases were less than 50 years old,54 cases were more than 50 years old.The positive rates of ACA were 20.9%and 5.6%(χ^2=4.626,P=0.031),respectively.The positive rates of anti-β2-GP1 were 25.4%and 7.4%(χ^2=5.534,P=0.019),respectively.ACA and anti-β2-GP1 in the two groups were statistically difference,but no statistically difference in sex(P>0.05).Conformance chi-square tests showed a correl
作者
程娟
陈礼文
唐伟
姚杰
周强
管世鹤
CHENG Juan;CHEN Liwen;TANG Wei;YAO Jie;ZHOU Qiang;GUAN Shihe(Department of Clinical Laboratory,the Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230601,China)
出处
《检验医学与临床》
CAS
2019年第9期1187-1190,共4页
Laboratory Medicine and Clinic
基金
安徽省自然科学基金资助项目(1808085MH229)
安徽医科大学校科学研究基金资助项目(2018xkj052)
关键词
脑梗死
抗心磷脂抗体
抗Β2糖蛋白1抗体
cerebral infarction
anti cardiolipin antibody
anti beta 2 glycoprotein 1 antibody
