摘要
自身免疫性肝病是一种由免疫介导的肝脏疾病,其发病机制复杂,至今尚未完全阐明。近些年来自身免疫性肝病的研究取得了许多新进展。本文从遗传易感性、肝脏免疫自稳、肠道微生物三个方面对自身免疫性肝病的发病机制作出综述。
Autoimmune liver disease is an immune-mediated liver disease whose pathogenesis is complex and the pathogenesis has not been fully elucidated.In recent years,the study of autoimmune liver disease has made a great progress.This article reviewed the recent pathogenesis in following three aspects:genetic susceptibility,liver immune auto-stability and intestinal microecology.
作者
彭雪莹
李慧
赵美云
史瑞雪
侯英键
王阳阳
PENG Xueying;LI Hui;ZHAO Meiyun;SHI Ruixue;HOU Yingjian;WANG Yangyang(Department of Gastroenterology,Affiliated Hospital of Hebei University,Baoding 071000;Clinical School of Medicine,Hebei University;Department of Outpatient,the No.3 Health Clinic of Retired Leaders,Shijiazhuang,Hebei Province;Hebei University,China)
出处
《胃肠病学和肝病学杂志》
CAS
2023年第5期588-591,598,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金(81200078)
河北大学医学学科培育项目(2020A12)
河北大学附属医院青年基金项目(2016Q001)
2021年度河北大学医学部课程建设培育项目(2021ALK-7)
河北大学“依托实习基地开展教学研究与实践”项目(2021-JG-SXJD28)
2022年政府资助临床医学优秀人才培养项目(361007)。
关键词
自身免疫性肝病
发病机制
遗传易感性
肝脏免疫自稳
肠道微生态
Autoimmune liver disease
Pathogenesis
Genetic susceptibility
Liver immune autostability
Intestinal microecology
