摘要
目的 探讨细胞质胸苷激酶(TK1)、组织多肽特异性抗原(TPS)及乳酸脱氢酶同工酶(LDH)在非霍奇金淋巴瘤(NHL)治疗前后水平变化及与预后生存的相关性。方法 选取2016年6月至2019年6月于河南大学淮河医院进行化疗治疗的113例NHL患者设为观察组,依据治疗效果将观察组分为缓解组和未缓解组;随访2年,了解观察组患者预后情况,根据随访结果将观察组分为生存组和死亡组。选取同期本院健康体检者118名设为对照组。比较各组间TK1、TPS、LDH水平,分析联合三项指标检测对NHL患者预后死亡的预测价值。结果 TK1、TPS、LDH水平分析:对照组<观察组化疗后<观察组化疗前,差异具有统计学意义(F=763.670、109.030、1175.280,P<0.05)。缓解组TK1、TPS、LDH水平低于未缓解组,差异具有统计学意义(t=8.466、4.567、14.182,P<0.05)。生存组NHL患者TK1、TPS、LDH水平低于死亡组,差异具有统计学意义(t=8.301、4.239、11.086,P<0.05)。TK1、TPS、LDH三者联合检测灵敏度(0.968)、特异度(0.952)、AUC(0.988)均高于各指标单一检测(P<0.05)。结论 临床可通过联合TK1、TPS、LDH检测提高NHL早期诊断率,三者可作为评估化疗治疗效果,判断患者预后的血清标志物。
Objective To explore the changes of cytoplasmic thymidine kinase(TK1),tissue polypeptide specific antigen(TPS)and lactate dehydrogenase(LDH)levels before and after treatment in patients with non-Hodgkin lymphoma(NHL)and their correlation with prognostic survival.Methods 113NHL patients treated with chemotherapy in Huaihe Hospital of Henan University from June 2016 to June 2019were selected as the observation group,and 118 patients who had a physical examination in our hospital during the same period were selected as the control group.The patient was followed up for 2 years to understand the prognosis of the patient in the observation group.The levels of TK1,TPS,and LDH among the groups were compared,and the value of the combined detection of the three indicators in predicting the prognostic death of NHL patients was analyzed.Results Analysis of TK1,TPS,LDH levels:control group observation group after chemotherapy observation group before chemotherapy,the difference was statistically significant(F=763.670,P<0.05;F=109.030,P<0.05;F=1175.280,P<0.05).The levels of TK1,TPS and LDH in the remission group were lower than those in the non-remission group,and the difference was statistically significant(t=8.466,P<0.05;t=4.567,P<0.05;t=14.182,P<0.05).The TK1,TPS and LDH levels of NHL patients in the survival group were lower than those in the death group,and the difference was statistically significant(t=8.301,P<0.05;t=4.239,P<0.05;t=11.086,P<0.05).The combined detection sensitivity(0.968),specificity(0.952),and AUC(0.988)of TK1,TPS,and LDH were higher than those of the single detection of each indicator(P<0.05).Conclusion In clinic,the combined detection of TK1,TPS,and LDH can improve the early diagnosis rate of NHL.The three can be used as serum markers to evaluate the effect of chemotherapy and judge the prognosis of patients.
作者
李向垒
许英君
张孟伟
刘灿
翟亚超
LI Xianglei;XU Yingjun;ZHANG Mengwei;LIU Can;ZHAI Yachao(Department of Oncology,Huaihe Hospital,Henan University,Kaifeng,Henan,China,475000)
出处
《分子诊断与治疗杂志》
2023年第4期585-588,593,共5页
Journal of Molecular Diagnostics and Therapy
