摘要
目的 探讨在慢性乙型肝炎出院患者中基于零缺陷理论的无缝隙管理策略,并观察其效果。方法 选取本院2019年1月-2020年5月慢性乙型肝炎出院患者108例按照随机数表分组,对照组出院后实施常规管理,研究组制定基于零缺陷理论的无缝隙管理策略并在出院后实施。比较2组管理期间复查、用药、生活起居依从率及6个月后丙氨酸转氨酶(alanine aminotransferase, ALT)正常率、慢性乙型肝炎病毒脱氧核糖核酸(Hepatitis B virus deoxyribonucleic acid, HBV DNA)转阴率、乙型肝炎E抗原(hepatitis B E antigen, HBeAg)转阴率、HBeAg/抗HBe转换率;比较2组管理前后生命质量变化。结果 研究组管理期间复查(94.44%∶77.78%)(χ^(2)=6.271,P<0.05)、用药依从率(92.59%∶70.37%)(χ^(2)=8.836,P<0.05)、生活起居依从率(96.30%∶81.48%)(χ^(2)=6.000,P<0.05)均高于对照组,差异有统计学意义,且研究组6个月后ALT正常率(90.57%∶75.00%)(χ^(2)=4.477,P<0.05)、HBV DNA转阴率(80.00%∶61.22%)(χ^(2)=4.212,P<0.05)、HBeAg转阴率(77.55%∶58.33%)(χ^(2)=4.118,P<0.05)、HBeAg/抗HBe转换率(73.47%∶52.08%)(χ^(2)=4.752,P<0.05)均高于对照组,差异有统计学意义;管理后2组各维度生命质量评分均高于管理前(研究组:t=10.185、11.369、10.417、11.525、12.361、10.956、13.067、12.004、12.156;对照组:t=6.543、6.182、6.009、6.254、6.636、6.718、6.543、7.016、6.251,P<0.05),且管理后研究组上述评分均高于对照组(t=2.748、3.442、5.145、3.540、2.818、2.723、3.108、4.100、3.390,P<0.05),差异均有统计学意义。结论 基于零缺陷理论的无缝隙管理应用于慢性乙型肝炎出院患者,不仅有助于提高其依从性,改善病情控制效果,还可提高生命质量。
Objective To explore the seamless management strategy based on zero defect theory in discharged patients with chronic hepatitis B and to observe its effect.Methods One hundred and eight discharged patients with chronic hepatitis B were divided into two groups according to random number table in our hospital during January 2019 to May 2020.The routine management was implemented in the routine group after discharge, and the study group developed seamless management strategy based on zero defect theory and implemented it after discharge.The compliance rates of reexamination, medication and daily life were compared between the two groups.The normal rates of alanine aminotransferase(ALT),negative conversion rates of Hepatitis B virus deoxyribonucleic acid(HBV DNA),negative conversion rates of hepatitis B E antigen(HBeAg) and HBeAg/anti HBe conversion rates were compared between the two groups after 6 months and the changes of quality of life before and after management were compared between the two groups.Results During the management period, the compliance rates of review(94.44% vs 77.78%)(χ^(2)=6.271,P<0.05),medication(92.59% vs 70.37%)(χ^(2)=8.836,P<0.05) and daily life(96.30% vs 81.48%)(χ^(2)=6.000,P<0.05) of the study group were higher than those of the routine group, with statistically significant differences.After 6 months, the ALT normal rate(90.57% vs 75.00%)(χ^(2)=4.477,P<0.05),HBV DNA negative conversion rate(80.00% vs 61.22%)(χ^(2)=4.212,P<0.05),HBeAg negative conversion rate(77.55% vs 58.33%)(χ^(2)=4.118,P<0.05) and HBeAg/anti HBE conversion rate(73.47% vs 52.08%)(χ^(2)=4.752,P<0.05) in the study group were higher than those in the routine group, with statistically significant differences.The quality of life scores of every dimension in the two groups after management were higher than those before management(the study group: t=10.185,11.369,10.417,11.525,12.361,10.956,13.067,12.004,12.156;the routine group: t=6.543,6.182,6.009,6.254,6.636,6.718,6.543,7.016,6.251,P<0.05),and the scores of the study
作者
亓琳
苏南南
王娜
王巧云
贾玉芹
庞海林
QI Lin;SU Nan-nan;WANG Na;WANG Qiao-yun;JIA Yu-qin;PANG Hai-lin(Taian Medical District,960 Hospital of PLA,Shandong 271000,China)
出处
《医学动物防制》
2023年第2期111-115,共5页
Journal of Medical Pest Control
基金
国家自然科学基金(81902318)。
关键词
零缺陷理论
无缝隙管理
慢性乙型肝炎
策略
效果
Zero defect theory
Seamless management
Chronic hepatitis B
Strategies
Effect
