摘要
目的探索干燥综合征(SS)中医证型与血常规参数、免疫学功能、疾病活动度的相关性。方法回顾性横断面研究。收集2021年2月-2022年6月江苏省中医院风湿免疫科242例SS住院患者的临床资料,比较各证型患者一般资料(性别、年龄、病程、BMI)、血常规参数[WBC、血红蛋白(Hb)、PLT、中性粒细胞计数(NEUT)、淋巴细胞计数(LYMPH)、中性粒细胞/淋巴细胞比值(NLR)]、免疫学指标[球蛋白、IgG、IgA、IgM、类风湿因子(RF)、抗SSA抗体、抗SSB抗体、抗Ro-52抗体]、炎症指标(ESR、CRP)、疾病活动度[干燥综合征疾病活动度指数(ESSDAI)、干燥综合征患者报告指数(ESSPRI)]的分布差异,对各证型与血常规参数、免疫学指标及炎症指标相关性进行二元Logistic回归分析。结果经辨证属气阴两虚证82例、阴虚津亏证61例、阴虚血瘀证59例、阴虚热毒证32例、其他证型8例,因其他证型病例数较少,故未纳入本研究。抗SSA抗体阳性率与IgM[OR(95%CI)为0.570(0.407,0.798)]呈负相关(P<0.01);抗SSB抗体及抗Ro-52抗体阳性率与LYMPH[OR(95%CI)分别为0.445(0.223,0.886)、0.457(0.224,0.932)]呈负相关(P<0.05),与IgG[OR(95%CI)分别为1.171(1.034,1.325)、1.159(1.014,1.325)]呈正相关(P<0.05);气阴两虚证与WBC[OR(95%CI)为2.590(1.120,5.987)]呈正相关(P<0.05),与LYMPH[OR(95%CI)为0.090(0.017,0.470)]、IgA[OR(95%CI)为0.728(0.553,0.959)]呈负相关(P<0.05);阴虚津亏证与PLT[OR(95%CI)为0.991(0.984,0.998)]、ESSPRI[OR(95%CI)为0.705(0.506,0.983)]、ESSDAI[OR(95%CI)为0.716(0.534,0.960)]呈负相关(P<0.05);阴虚血瘀证与IgA[OR(95%CI)为1.184(1.028,1.363)]呈正相关(P<0.05),与抗SSB抗体阳性率[OR(95%CI)为0.247(0.093,0.659)]呈负相关(P<0.05);阴虚热毒证与IgA[OR(95%CI)为1.368(1.037,1.803)]呈正相关(P<0.05),与抗SSB抗体阳性率[OR(95%CI)为0.278(0.085,0.909)]呈负相关(P<0.05)。结论阴虚血瘀证、阴虚热毒证SS患者免疫球蛋白水平、炎症指标及疾病活动度较高,易�
Objective To explore the correlation between Traditional Chinese Medicine(TCM)syndrome types of Sjögren syndrome(SS)and blood test parameters,immunological function and disease activity.Methods A retrospective cross-sectional study was conducted.The clinical data of 242 SS inpatients in the Rheumatology and Immunology Department of Jiangsu Province Hospital of TCM from February 2021 to June 2022 were analyzed retrospectively.We compared the general data(gender,age,course of disease,BMI),blood parameters[WBC,hemoglobin(Hb),PLT,neutrophil count(NEUT),lymphocyte count(LYMPH),neutrophil/lymphocyte ratio(NLR)],immunological indicators(globulin,IgG,IgA,IgM,rheumatoid factor(RF),anti-SSA antibody,anti-SSB antibody,anti-Ro-52 antibody).The distribution difference of disease activity[Disease Activity Index of Sjogren's syndrome(ESSDAI)and Patient Report Index of Sjogren's syndrome(ESSPRI)],the correlation between each syndrome type and blood routine parameters,immunological indicators and inflammatory indicators was analyzed by binary logistic regression.Results They were divided into 82 cases of qi yin deficiency syndrome,61 cases of yin deficiency and fluid deficiency syndrome,59 cases of yin deficiency and blood stasis syndrome,32 cases of yin deficiency and heat toxin syndrome,and 8 cases of other syndrome types.Because the number of other syndrome types was small,they were not included in this study.Logistic regression analysis showed that the positive rate of anti SSA antibody was negatively correlated with IgM[OR(95%CI)=0.570(0.407,0.798)](P<0.01).The positive rates of anti SSB antibody and anti Ro-52 antibody were negatively correlated with LYMPH[OR(95%CI)=0.445(0.223,0.886),0.457(0.224,0.932),respectively](P<0.05).The positive rates of anti SSB antibody and anti Ro-52 antibody were positively correlated with IgG[OR(95%CI)=1.171(1.034,1.325),1.159(1.014,1.325),respectively](P<0.05).Qi Yin deficiency syndrome was positively correlated with WBC[OR(95%CI)=2.590(1.120,5.987)](P<0.05),and negatively correlated with LY
作者
杨欣莹
甘可
陆燕
Yang Xinying;Gan Ke;Lu Yan(Department of Rheumatology,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;The First Clinical School of Nanjing University of Chinese Medicine,Nanjing 210023China;Department of Rheumatology,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China)
出处
《国际中医中药杂志》
2023年第4期397-403,共7页
International Journal of Traditional Chinese Medicine
基金
江苏省研究生实践创新计划项目(SJCX22_0725)
江苏省中医院高峰学术人才项目(y2021rc54)。
关键词
干燥综合征
辨证分型
血常规参数
免疫学功能
疾病活动度
Sjogren's syndrome
Syndrome differentiation classification
Blood routine parameters
Immunological function
Disease activity
