摘要
衰老、缺氧等诱发的记忆缺失极其普遍,因此,探索记忆的产生、存储和检索等机制对于日常生活及临床工作均具重大意义。而记忆的存储及检索或与计算机有相似之处,我们整理了记忆的机械基础-网格编码理论的研究进展。某些疾病(如阿尔茨海默病)或病理状态(如衰老、缺氧)导致的记忆缺失可能与机械敏感蛋白质踝蛋白的折叠异常有关。踝蛋白可以通过结构域状态的改变,以二进制的形式存储或更新机械力微小变化的信息,并引发神经元内配体的重新分配等化学过程,从而动态调节突触活动,将记忆以网格编码的二进制格式储存在大脑中。
Memory loss induced by aging and hypoxia is very common,so exploring the mechanism of memory production,storage and retrieval is of great significance to daily life and clinical work.The storage and retrieval of memory is probably similar to the computer.We summarized the research progress of MeshCODE theory,the mechanical basis of memory.Memory loss in certain diseases(such as Alzheimer’s disease)or pathological conditions(such as aging,lack of oxygen)may be associated with abnormal folding of talin,a mechanosensitive protein.It can dynamically regulate synaptic activity by changing the state of the domain,storing or updating information about small changes in mechanical forces in binary form,and initiating chemical processes such as ligand redistribution in neurons,so that memory is stored in the brain in a binary format,known as the MeshCODE theory.
作者
陈荟竹
方璇
陶昶煜
张卫光
CHEN Hui-zhu;FANG Xuan;TAO Chang-yu;ZHANG Wei-guang(Clinical Eight-Year,Peking University Health Science Center,Beijing 100191,China;Department of Human Anatomy and Histology and Embryology,School of Basic Medicine,Peking University Health Science Center,Beijing 100191,China)
出处
《解剖学报》
CAS
CSCD
北大核心
2023年第2期249-254,共6页
Acta Anatomica Sinica
基金
北京市自然科学基金海淀前沿项目(19L2053)。
