摘要
目的 探讨两种联合用药方案对帕金森患者的氧化应激及炎症反应的影响。方法 选取2019年6月—2021年5月到商丘市第一人民医院治疗的56例帕金森患者,随机数表法任意分成A、B两组,各28例,其中A组给予神经节苷脂联合左旋多巴用药治疗、B组给予盐酸苯海索片联合甲磺酸雷沙吉兰片治疗,疗程为2个月。比较两组联合药物的临床疗效,以及患者在治疗前后的氧化应激指标水平[超氧化物歧化酶(SOD)、一氧化氮合酶(NOS)、循环谷胱甘肽过氧化物酶(CGP)、对氧磷脂酶(PON1)]和炎症反应指标水平[白细胞介素-6(IL-6)、干扰素-α(IFN-α)、白细胞介素-12p70(IL-12p70)、白细胞介素-17A(IL-17A)];观察记录两组患者在治疗期间的不良反应。结果 治疗后,B组联合用药方案的总有效率(96.43%)高于A组(82.14%),差异均有统计学意义(P<0.05);两组患者的氧化应激指标水平和炎症反应指标水平均有不同程度的改善,其中B组患者的氧化应激指标SOD、NOS、CGP、PON1以及炎症反应指标IL-17A均高于A组,且炎症反应指标IL-6、IFN-α、IL-12p70均低于A组,差异均有统计学意义(P<0.05);比较两组患者治疗前后得分从行为及精神,生活能力,运动功能及运动并发症等四个方面展开,治疗前两组得分比较,无显著差异(P>0.05),治疗后B组患者UPDRS得分明显低于A组,差异有统计学意义(P<0.05);两组患者不良反应发生率差异统计学意义(P>0.05)。结论 神经节苷脂联合左旋多巴和盐酸苯海索片联合甲磺酸雷沙吉兰片两种联合用药方案均能改善帕金森患者的氧化应激和炎症反应,但盐酸苯海索片联合甲磺酸雷沙吉兰片用药方案优于神经节苷脂联合左旋多巴用药方案,更有效的改善帕金森患者的氧化应激和炎症反应,改进患者的精神心理状况、运动功能和日常日常生活能力,具备较高的安全系数。
Objective To study the effects of a combination of two drugs on oxidative stress and inflammatory response in patients with Parkinson’s disease. Methods Totally 56 patients with Parkinson’s disease admitted to Shangqiu First People’s Hospital from June 2019 to May 2021 were randomly divided into two groups A and B by random number table method, with 28 patients in each group. Group A was treated with ganglioside combined with levodopa, and group B was treated with benhyisol hydrochloride combined with Resagiline mesylate tablets, with A course of 2 months. The clinical efficacy of combined drugs was compared between the two groups. And the levels of oxidative stress indexes [superoxide dismutase(SOD), nitric oxide synthase(NOS), circulating glutathione peroxidase(CGP), para-oxygen-phospholipase(PON1)] and inflammatory response indexes [interleukin-6(IL-6), interferon-α(IFN-α), interleukin-12P7] before and after treatment 0(IL-12P70), interleukin-17A(IL-17A)];The adverse reactions of 2 groups were observed and recorded during treatment. Results After treatment, the overall response rate was higher in group B(96.43%) than in group A(82.14%),differences were considered statistically significant(P<0.05);The levels of oxidative stress indicators and inflammatory response indicators in the two groups were improved to varying degrees. The oxidative stress indicators SOD, NOS, CGP, PON1 and inflammatory response indicators IL-17A in group B were higher than those in group A, and the inflammatory response indicators IL-6 and IFN-α, IL-12p70 lower than those of the group A, the differences were considered statistically significant(P<0.05);UPDRS scores before and after treatment were compared between the two groups in four domains: behavior and mental, living ability, motor function, and motor complications. There was no significant difference between the two groups before treatment(P>0.05). After treatment, the scores of behavior, spirit and emotion, ability of daily living, motor function and motor complications
作者
刘亭
徐航
LIU Ting;XU Hang(First Department of Neurology,Shangqiu the First People's Hospital,Shangqiu,Henan 476000,China;Department of Neurology,Zhoukou the First People's Hospital,Zhoukou,Henan 466700,Chian)
出处
《医药论坛杂志》
2023年第3期94-97,F0003,共5页
Journal of Medical Forum
关键词
帕金森
氧化应激
炎症反应
盐酸苯海索片
甲磺酸雷沙吉兰片
Parkinson’s disease
Oxidative stress
Inflammatory response
Phenhythol hydrochloride tablet
Resagiline mesylate tablets
