摘要
帕金森病(Parkinson’s disease,PD)是常见的中枢神经系统退行性疾病之一,其主要病理学特征是中脑黑质部的多巴胺(dopamine,DA)能神经元选择性丢失。虽然已发现基因易感性、衰老、环境毒素等因素与PD发病有关,但导致DA能神经元退行性死亡的细胞分子机制仍不明确。DA代谢是DA能神经元中的重要生理过程,其过程与黑质DA能神经元丢失密切相关,DA代谢异常参与了PD神经元变性相关的诸多病理学过程,例如铁代谢异常、α-突触核蛋白异常聚集、内质网应激、蛋白质降解功能障碍、神经炎症反应等。本文就DA代谢异常在PD相关病理学过程中的作用进行综述。
Parkinson’s disease(PD),one of the most frequent neurodegenerative disorders,is characterized by the selective loss of dopaminergic neurons in the substantia nigra(SN).Genetic vulnerability,aging,environmental insults are believed to contribute to the pathogenesis of PD.However,the cellular and molecular mechanism of dopaminergic neurons degeneration remains incompletely understood.Dopamine(DA)metabolism is a cardinal physiological process in dopaminergic neurons,which is closely related to the loss of dopaminergic neurons in the SN.DA metabolism takes part in several pathological processes of PD neurodegeneration,such as iron metabolism disturbance,α-synuclein mis-folding,endoplasmic reticulum stress,protein degradation dysfunction,neuroinflammatory response,etc.In this review,we will describe altered DA metabolism and its contributions to PD pathogenesis.
作者
王晓蕊
朱松鑫
温晓鸣
谢俊霞
宋宁
WANG Xiao-Rui;ZHU Song-Xin;WEN Xiao-Ming;XIE Jun-Xia;SONG Ning(Department of Physiology and Pathophysiology,School of Basic Medicine,Institute of Brain Science and Disease,Qingdao University,Qingdao 266071,China)
出处
《生理学报》
CAS
CSCD
北大核心
2021年第1期89-102,共14页
Acta Physiologica Sinica
基金
supported by grants from the National Natural Science Foundation of China(No.31871049)
the National Students’Innovation and Entrepreneurship Training Program of China(No.201911065011)。
