摘要
目的 观察艾拉莫德联合布洛芬治疗类风湿关节炎的临床效果。方法 选取2018年10月—2020年10月湖南省邵阳市中心医院接收的类风湿关节炎患者100例,按照随机数字表法分为观察组和对照组,每组50例。对照组给予布洛芬治疗,观察组在对照组的基础上联合艾拉莫德治疗,2组均治疗10周。比较2组治疗效果,关节肿胀、关节疼痛、晨僵症状改善情况,治疗前后疼痛视觉模拟评分(VAS)、Cincinnati膝关节评分、炎性因子及不良反应。结果 观察组治疗总有效率为94.00%,高于对照组的80.00%(χ^(2)=4.332,P=0.037);观察组关节肿胀、关节压痛、关节晨僵改善率均高于对照组(P<0.05);治疗10周后,2组VAS评分均低于治疗前,Cincinnati膝关节评分均高于治疗前,且观察组低/高于对照组(P<0.01);2组TNF-α、IL-4水平均低于治疗前,且观察组低于对照组(P<0.01);观察组不良反应总发生率为4.00%,对照组不良反应总发生率为10.00%,2组比较差异无统计学意义(χ^(2)=0.614,P=0.433)。结论 艾拉莫德联合布洛芬治疗类风湿关节炎的疗效显著,且安全性好,值得临床推广应用。
Objective To observe the clinical effect of eramod combined with ibuprofen in the treatment of rheumatoid arthritis. Methods A total of 100 patients with rheumatoid arthritis received by the Central Hospital of Shaoyang from October 2018 to October 2020 were selected, and they were randomly divided into observation group and control group according to random number table method, with 50 patients in each group. The control group was treated with ibuprofen, and the observation group was treated with elamod on the basis of the control group, both groups were treated for 10 weeks. The treatment effect, improvement of joint swelling, joint pain, morning stiffness, pain visual analog score(VAS), Cincinnati knee joint score, inflammatory factors and adverse reactions of the two groups were compared. Results The total effective rate of patients in the observation group was 94.00%, higher than 80.00% in the control group(χ^(2)=4.332, P=0.037);The improvement rate of joint swelling, joint tenderness and joint morning stiffness in the observation group were higher than those in the control group(P<0.05);After 10 weeks of treatment, the VAS scores in both groups were lower than those before treatment, Cincinnati knee joint scores were higher than those before treatment, and the observation group were lower/higher than the control group(P<0.01);The TNF-α、 IL-4 were lower than those before treatment, and the observation group were lower than the control group(P<0.01);The total incidence of adverse reactions in the observation group was 4.00%, while in the control group was 10.00%, there was no significant difference between the two groups(χ^(2)=0.614, P=0.433). Conclusion Eramod combined with ibuprofen in the treatment of rheumatoid arthritis has significant efficacy and good safety, which is worthy of clinical application.
作者
彭延刚
PENG Yangang(Department of Rheumatology&Immunology,the Central Hospital of Shaoyang,Hunan Province,Shaoyang 422000,China)
出处
《临床合理用药杂志》
2023年第7期27-29,33,共4页
Chinese Journal of Clinical Rational Drug Use
