摘要
目的:调查乌鲁木齐地区2型糖尿病患者的维生素D营养状态。方法:选取2015年5月—2020年6月新疆医科大学第二附属医院内分泌科收治的2型糖尿病患者1631例。检测所有患者血25-(OH)D水平,并结合调查对象的性别、年龄、检测时间和糖化血红蛋白水平进行统计学分析。结果:调查对象血25-(OH)D平均水平为10.24(6.35~15.25)ng/mL,男女性比较,差异无统计学意义(P>0.05)。18~40岁组与41~50岁组、51~60岁组、61~70岁组和>70岁组相比,血25-(OH)D水平较低,差异有统计学意义(Z值分别为-2.118、-2.682、-1.979、-3.146,P值均<0.05)。秋季组2型糖尿病患者血25-(OH)D水平较其他3组高,差异有统计学意义(Z值分别为-5.656、-6.517、-10.741,P值均<0.01)。秋季组血25-(OH)D充足的例数占比为6.54%,较春季组、夏季组和冬季组高,差异有统计学意义(χ^(2)值分别为14.207、14.384、14.749,P值均<0.01)。不同营养状态组,调查对象糖化血红蛋白水平方面比较,差异无统计学意义。2型糖尿病患者糖化血红蛋白水平与血25-(OH)D水平无线性相关关系。结论:乌鲁木齐地区2型糖尿病患者普遍存在维生素D缺乏,季节可以对患者维生素D水平产生影响,2型糖尿病患者在平日注意维生素D的补充的同时,应在春季和冬季加强补充。室内办公的2型糖尿病患者增加户外活动时间,以提高维生素D水平。
Objective To investigate the level of serum 25-hydroxyvitamin D in the patients with type 2 diabetes mellitus in Urumqi.Methods The clinical data of 1631 cases of patients with type 2 diabetes mellitus were retrospectively analyzed.The data were included gender,age,the level of serum 25-hydroxyvitamin D and glycosylated hemoglobin,testing time.Results The level of serum 25-hydroxyvitamin D in 1631 cases was 10.24(6.35~15.25)ng/mL,There was no statistically signifcant difference between males and females.Compared with the 41 to 50 years old,51 to 60 years old,61 to 70 years old and>70 years old groups,the level of serum 25-hydroxyvitamin D with 18 to 40 years old group was lower,and the difference was statistically signifcant(Z=-2.118,-2.682,-1.979,-3.146,P<0.05).The level of serum 25-hydroxyvitamin D with autumn group was higher than that with spring group,summer group and winter group,and the difference was statistically signifcant(Z=-5.656,-6.517,-10.741,P<0.01).There was no statistically signifcant difference in the level of serum glycosylated hemoglobin with different nutritional status groups,and there was no linear correlation between the level of serum glycosylated hemoglobin and the level of serum 25-hydroxyvitamin D with type 2 diabetes mellitus.Conclusion Vitamin D defciency is prevalent in patients with type 2 diabetes mellitus in Urumqi.Season is related to the level of serum 25-hydroxyvitamin D.Patients with type 2 diabetes mellitus should pay attention to supplement vitamin D,especially in spring and winter.Patients with type 2 diabetes mellitus who work indoors should spend more time outdoors to improve the level of serum 25-hydroxyvitamin D.
作者
杨雯雯
杨晶晶
王宁
YANG Wenwen;YANG Jingjing;WANG Ning(The Second Department of Comprehensive Internal Medicine of the First Afliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830063,China;Department of Endocrinology,the Second Afliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China)
出处
《医药前沿》
2023年第4期33-36,40,共5页
Journal of Frontiers of Medicine
基金
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2020-19)。
