摘要
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是常见的慢性间质性纤维化疾病。纤维化进程中,肌成纤维细胞异常活化,胶原蛋白大量沉积,肺组织生物力学特征发生显著变化。研究表明,生物力学因素在IPF疾病发生发展中发挥重要作用。本文对IPF进程中肺组织、细胞生物力学特性的变化以及生物力学信号的转导进行系统综述,并总结IPF生物力学特征的体外再现及靶向生物力学的治疗策略,为IPF临床防治提供参考。
Idiopathic pulmonary fibrosis(IPF) is a common chronic interstitial fibrotic disease.During the fibrosis process,myofibroblasts are abnormally activated,collagen is deposited in large quantities and the biomechanical characteristics of lung tissue are significantly altered.In this paper,a systematic review about the changes in lung tissues,cellular biomechanical properties and biomechanical signals during the process of IPF was presented,and the in vitro reproduction of biomechanical features and therapeutic strategies for targeting biomechanics was summarized,so as to provide references for clinical prevention and treatment of IPF.
作者
孙美好
金凡力
李建生
任徽
刘含
SUN Meihao;JIN Fanli;LI Jiansheng;REN Hui;LIU Han(Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan & Ministry of Education of China, Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine;Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University;Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University)
出处
《医用生物力学》
CAS
CSCD
北大核心
2023年第1期195-201,共7页
Journal of Medical Biomechanics
基金
国家自然科学基金项目(11902245)
中国博士后科学基金项目(2021M690938)
河南省重点研发与推广专项(科技攻关)(222102310183)
河南中医药大学研究生科研创新类项目(2021KYCX042)。
关键词
特发性肺纤维化
生物力学
基质硬度
体外模型
靶向治疗
idiopathic pulmonary fibrosis
biomechanics
matrix stiffness
in-vitro models
targeted therapies
