摘要
特发性肺纤维化(IPF)是一种进行性瘢痕形成的疾病,死亡率高,已引起广泛关注。上皮间质转化(EMT)是肺纤维化进程中重要的一环,而肺组织生物力学特性的变化对其有重要影响。本文总结了近年IPF-EMT中肺组织生物力学微环境的变化规律,并对肺纤维化中力学微环境的改变对EMT进程的影响、力学因素对EMT肺泡上皮细胞行为的影响和EMT中生物力学信号的传导进行了系统综述,以期为IPF的防治研究提供新的参考。
Idiopathic pulmonary fibrosis(IPF)is a progressive scar-forming disease with a high mortality rate that has received widespread attention.Epithelial mesenchymal transition(EMT)is an important part of the pulmonary fibrosis process,and changes in the biomechanical properties of lung tissue have an important impact on it.In this paper,we summarize the changes in the biomechanical microenvironment of lung tissue in IPF-EMT in recent years,and provide a systematic review on the effects of alterations in the mechanical microenvironment in pulmonary fibrosis on the process of EMT,the effects of mechanical factors on the behavior of alveolar epithelial cells in EMT and the biomechanical signaling in EMT,in order to provide new references for the research on the prevention and treatment of IPF.
作者
李明艳
孙美好
贾渊博
任徽
刘含
LI Mingyan;SUN Meihao;JIA Yuanbo;REN Hui;LIU Han(Henan University of Chinese Medicine,Academy of Chinese Medicine Sciences,Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan&Ministry of Education of PR China,Henan Key Laboratory of Chinese Medicine for Respiratory Disease,Zhengzhou 450016,P.R.China;Bioinspired Engineering&Biomechanics Center,Xi'an Jiaotong University,Xi'an 710049,P.R.China;Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Xian Jiaotong University,Xi'an 71006l,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
北大核心
2023年第4期632-637,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金(11902245)
中国博士后科学基金(2021M690938)
河南省重点研发与推广专项(科技攻关)(222102310183)
中国博士后特别资助(2022T150197)。
关键词
肺纤维化
基质刚度
机械拉伸
生物力学微环境
生物力学感受器
Pulmonary fibrosis
Matrix stiffness
Mechanical stretch
Biomechanical microenvironment
Biomechanical receptors
