摘要
抽动障碍是儿童期常见的以运动抽动和(或)发声抽动为主要特征的神经精神疾病,其发病机制与脑内局部多巴胺水平增高有关。阿立哌唑是新型的第3代非典型抗精神病药,是治疗抽动障碍的有效治疗药物之一。但目前阿立哌唑用于抽动障碍的治疗属于超说明书用药,且治疗窗尚不明确,药动学存在较大个体差异。为提高阿立哌唑治疗儿童抽动障碍的有效性和安全性,考察阿立哌唑在抽动障碍儿童群体中的药动学作用规律,探明其个体差异的产生机制意义重大。本文就目前阿立哌唑治疗儿童抽动障碍的药动学研究现状及意义作一综述。
Tic disorder is a common childhood neuropsychiatric disorder characterized by motor tics and/or vocal tics.The pathogenesis of tic disorder is related to the increase of local dopamine level in the brain.Aripiprazole is a new third-generation atypical antipsychotic drug and one of the effective treatments for tic disorder.However,the use of aripiprazole is off-label administration in the treatment of tic disorder,and the therapeutic window is not yet clear.In addition,there are large individual variabilities in pharmacokinetics.In order to improve the efficacy and safety of aripiprazole in the treatment of tic disorders in children,it is of great significance to investigate the pharmacokinetics of aripiprazole and to explore the mechanism of individual differences.This article reviews the current study status and significance of the pharmacokinetics for aripiprazole in the treatment of children with tic disorder.
作者
辛莹莹
石亮
梅艳
王俊
李梦婷
庹亚莉
李思婵
汪洋
刘智胜
高柳柳
Ying-Ying XIN;Liang SHI;Yan MEI;Jun WANG;Meng-Ting LI;Ya-Li TUO;Si-Chan LI;Yang WANG;Zhi-Sheng LIU;Liu-Liu GAO(Wuhan Children’s Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430016,China)
出处
《药物流行病学杂志》
CAS
2023年第2期221-226,共6页
Chinese Journal of Pharmacoepidemiology
基金
国家自然科学基金青年科学基金项目(81600123)
武汉市医学科研项目面上项目(WX21A14)。
关键词
抽动障碍
阿立哌唑
药动学
Tic disorder
Aripiprazole
Pharmacokinetics
