摘要
马钱子中可以提取出士的宁、马钱子碱、环烯醚萜苷等多种具有生物活性的化合物。综述了马钱子主要提取物在神经系统、免疫系统、肌肉骨骼系统、抑制病原微生物和抗肿瘤方面的药理机制,并分析了其活性成分的临床应用价值。结果发现马钱子活性成分具有可兴奋中枢神经系统,提高感觉器官的功能,有效减轻炎症反应,有较强的镇痛抗炎功能,此外还对多种肿瘤具有抑制效果,未来有望开发成为抗血管增生和抗癌治疗药物。
Strychnos nuxvomica L.is a traditional Chinese medicine,which has the effect of relieving pain and reducing swelling.Modern pharmacological studies have found that strychnine,brucine,iridoid glycosides and other bioactive compounds can be extracted from Semen Strychni.To understand the clinical value of nux vomica and its active ingredients,we collected relevant research results,explored the pharmacological mechanisms of its main extract in nervous system,immune system,musculoskeletal system,inhibiting pathogenic microorganisms and anti-tumor,respetively,and then analyzed the clinical application value The results show that the active components of nux vomica can excite the central nervous system,improve the function of sensory organs,reduce inflammation effectively,ease pain,and reduce inflammation,in addition to playing a role of inhibiting a variety of tumors.Possibly,it can be developed as anti-angiogenic and anticancer drugs in the future.With the indepth study of the pharmacological mechanism of nux vomica,more confirmed evidences of pharmacology and experiment will be mastered to guide the clinical application.
作者
范东伟
廖姣姣
冯玉婷
陶立元
FAN Dongwei;LIAO Jiaojiao;FENG Yuting;TAO Liyuan(Department of Orthopaedics,Peking University Third Hospital,Beijing 100191,China;Beijing Key Laboratory for Spine Disease Research,Beijing 100191,China;Engineering Center of the Ministry of Education for Bone and Joint Precision Medicine,Peking University,Beijing 100191,China;Clinical Epidemiology Research Center,Peking University Third Hospital,Beijing 100191,China;Beijing University of Chinese Medicine,Beijing 102488,China;Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《科技导报》
CAS
CSCD
北大核心
2023年第3期37-43,共7页
Science & Technology Review
基金
国家自然科学基金项目(42277420,41931291,82004210)。
关键词
马钱子
士的宁
马钱子碱
药理机制
Strychnos nux-vomica
strychnine
brucine
pharmacological mechanism
