摘要
目的探讨噻托溴铵粉吸入剂与喷雾剂治疗慢性阻塞性肺疾病(COPD)患者的临床疗效。方法回顾性分析我院2018年5月—2020年5月收治的198例COPD患者,根据噻托溴铵剂型不同将其分为喷雾剂组109例与粉吸入剂组89例。比较两组的治疗效果、睡眠质量评分、疲劳症状评分以及不良反应发生率。结果治疗后,喷雾剂组治疗总有效率高于粉吸入剂组,两组比较差异有统计学意义(χ^(2)=4.940,P<0.05);喷雾剂组各项睡眠质量评分、疲劳症状评分均低于粉吸入剂组,两组比较差异均有统计学意义(t=10.582、9.190、8.563、7.261、7.376、9.999、21.340、9.769、11.569、6.043、7.594,均P<0.05);但两组不良反应发生率比较,差异无统计学意义(χ^(2)=1.711,P>0.05)。结论噻托溴铵喷雾剂治疗COPD,可显著改善患者夜间睡眠质量和疲劳症状,疗效优于粉吸入剂,应用价值较高。
Objective To explore the clinical efficacy of tiotropium bromide powder inhalation and spray on patients with chronic obstructive pulmonary disease(COPD).Methods A retrospective analysis was performed on the data of 198 patients with COPD who were admitted to the hospital between May 2018 and May 2020.According to the different dosage forms of tiotropium bromide,patients were divided into the inhalation group(n=89)and the spray group(n=109).Therapeutic effects,the score of sleep quality,the score of fatigue symptoms and the incidence rate of adverse reactions were compared between the two groups.Results After treatment,the total response rate in the spray group was significantly higher than that in the inhalation group,the difference between the two groups was statistically significant(χ^(2)=4.940,P<0.05);The scores of sleep quality and fatigue in the spray group were all lower than those of the inhalation group,the difference between the two groups was statistically significant(t=10.582,9.190,8.563,7.261,7.376,9.999,21.340,9.769,11.569,6.043,7.594,all P<0.05);There was no significant difference in the incidence rate of adverse reactions between the two groups(χ^(2)=1.711,P>0.05).Conclusion Tiotropium bromide spray can significantly improve the sleep quality at night and fatigue symptoms of patients with COPD,and the effect is better than the powder inhalation,with high application value.
作者
曹昌琳
CAO Chang-lin(Department of Respiratory and Critical Care Medicine,Chenzhou First People's Hospital,Chenzhou,Hunan,423000,China)
出处
《中国冶金工业医学杂志》
2023年第1期1-3,共3页
Chinese Medical Journal of Metallurgical industry
关键词
噻托溴铵粉吸入剂
噻托溴铵喷雾剂
慢性阻塞性肺疾病
睡眠质量
Tiotropium bromide powder inhalation
Tiotropium bromide spray
Chronic obstructive pulmonary disease
Sleep quality
