摘要
目的:观察健脾化瘀法治疗脾虚痰瘀型胰岛素抵抗型多囊卵巢综合征(PCOS)的临床疗效。方法:100例患者随机分为治疗组和对照组,每组50例,对照组服用达英-35、二甲双胍,治疗组在西药基础上加服健脾化瘀中药;治疗3个月经周期,停药后1个月观察临床疗效。通过组间及组内治疗前后中医临床症状积分、卵巢体积变化及黄体生成素(luteinizing hormone,LH)、睾酮(testosterone,T)、空腹胰岛素(fasting insulin fins,FINS)的变化来评价治疗效果。结果:治疗组临床有效率明显高于对照组(P<0.05);两组患者治疗后症状积分均明显下降,卵巢体积均有不同程度缩小,组间比较差异具有统计学意义(P<0.05);经治疗后两组患者LH、T、FINS值均较本组治疗前明显改善,治疗后LH组间比较差异具有统计学意义(P<0.05)。结论:健脾化瘀法治疗胰岛素抵抗型PCOS患者可纠正胰岛素抵抗状态,改善临床症状。
Objective:To observe the clinical efficacy of the method of invigorating spleen and removing blood stasis in the treatment of insulin-resistant polycystic ovarian syndrome due to spleen deficiency and phlegm stasis.Methods:The patients were randomly divided into treatment group and control group,with 50 cases in each group.Patients in the control group took Daying-35 and metformin,while patients in the treatment group took Chinese herbs of strengthening spleen and removing blood stasis in addition to Western medicines.The clinical efficacy was observed for 3 menstrual cycles and 1 month after discontinuation of the drug.The treatment effects were evaluated by the pre-and post-treatment TCM clinical symptom scores,ovarian volume changes and changes in luteinizing hormone(LH),testosterone(T)and fasting insulin fins(FINS)between groups and within groups.Results:The clinical efficiency of the treatment group was significantly higher than that of the control group(P<0.05);The treated patients all had a significant decrease in symptom scores and different degrees of ovarian volume reduction,with statistically significant differences between groups(P <0.05);After treatment,LH,T and FINS values improved significantly compared with those before treatment,and the difference between groups after LH treatment was statistically significant(P<0.05).Conclusion:The treatment of insulinresistant PCOS patients with the method of strengthening the spleen and removing blood stasis can correct the insulin resistance status and improve clinical symptoms.
作者
张爱萍
侯玉华
吴琴玲
张荣荣
刘立慧
赵玉玲
贺诗雨
张路路
Zhang Aiping;Hou Yuhua;Wu Qinlin;Zhang Rongrong;Liu Lihui;Zhao Yulin;He Shiyu;Zhang Lulu(Shenzhen Pingle Orthopaedics Hospital,Shenzhen Guangdong 518000)
出处
《山西中医药大学学报》
2022年第5期460-464,共5页
Journal of Shanxi University of Chinese Medicine
基金
广东省深圳市坪山区医疗卫生系统科研立项资助项目(201930)。
关键词
多囊卵巢综合征
胰岛素抵抗
健脾化瘀法
polycystic ovarian syndrome
insulin-resistance
invigorating spleen and removing blood stasis
