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屈螺酮炔雌醇片(Ⅱ)联合二甲双胍治疗多囊卵巢综合征的效果观察 被引量:6

Effect observation of drospironone ethinylestradiol tablets(Ⅱ)combined with metformin in the treatment of polycystic ovary syndrome
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摘要 目的探讨屈螺酮炔雌醇片(Ⅱ)联合二甲双胍治疗多囊卵巢综合征(PCOS)的效果。方法选择2018年7月至2019年7月本院收治的PCOS患者98例,并按随机数表法分为两组,每组49例。予以对照组螺酮炔雌醇片(Ⅱ),观察组接受螺酮炔雌醇片(Ⅱ)联合二甲双胍治疗,比较两组治疗后排卵与妊娠情况,对比治疗前、治疗6个疗程后的血清性激素[卵泡雌激素(FSH)、黄体生成素(LH)、雌二醇(E2)及睾酮(Ts)]与胰岛素抵抗(IR)水平。结果观察组排卵率73.47%、妊娠率57.14%均较对照组的48.98%、28.57%高,差异有统计学意义(P <0.05)。两组治疗前血清性激素、IR水平比较,差异无统计学意义(P> 0.05);观察组治疗后FSH、LH、E2、Ts及IR水平均较对照组低,差异有统计学意义(P <0.05)。结论屈螺酮炔雌醇片(Ⅱ)联合二甲双胍治疗PCOS效果确切,能明显恢复机体内分泌功能,改善血清性激素与IR水平,有助于改善排卵与妊娠情况。 Objective To investigate the effect of drospirenone estradiol(Ⅱ)combined with metformin in the treatment of polycystic ovary syndrome(PCOS). Methods 98 PCOS patients admitted in our hospital from July 2018 to July 2019 were selected and divided into two groups according to the random number table method, with 49 patients in each group. The control group was given spirostilbestrol(Ⅱ), and the observation group received spirostilbestrol (Ⅱ)combined with metformin. The ovulation and pregnancy were compared between the two groups after treatment, and the serum before and after 6 courses of treatment were compared. Sex hormones[follicular estrogen(FSH), luteinizing hormone(LH), estradiol(E2), and testosterone(Ts)]and insulin resistance(IR)levels. Results The ovulation rate and pregnancy rate of the observation group were 73.47% and 57.14% respectively, which were higher than 48.98% and28.57% of the control group(P < 0.05). There was no significant difference in the levels of serum sex hormone and IR between the two groups before treatment(P > 0.05);the levels of FSH, LH, E2, TS and IR in the observation group after treatment were lower than that of the control group(P < 0.05). Conclusions Drospironone ethinylestradiol tablets (Ⅱ)combined with metformin is effective in the treatment of PCOS. It can significantly restore endocrine function, improve serum sex hormone and IR levels, and help to improve ovulation and pregnancy.
作者 闫蕤 YAN Rui(International Hospital of Urumqi,Urumqi,830019,China)
出处 《新疆医学》 2021年第1期56-58,62,共4页 Xinjiang Medical Journal
关键词 多囊卵巢综合症 屈螺酮炔雌醇片(Ⅱ) 二甲双胍 性激素 胰岛素抵抗 Polycystic Ovary Syndrome Drospirenol Estradiol(Ⅱ) Metformin Sex Hormones Insulin Resistance
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