摘要
隐匿性乙肝病毒感染(occult hepatitis B virus infection,OBI)是乙肝病毒(HBV)感染的特殊类型,即乙肝表面抗原(HBsAg)检测阴性,但HBV核酸检测为阳性。本文主要综述了OBI在献血者中的流行情况、传播可能性和检测建议。世界部分国家和国内具有代表性地区献血者OBI的流行率各不相同,分析表明非洲地区献血者OBI流行率远远高于世界其他地区,我国南方地区献血者OBI流行率高于北方地区。献血者OBI存在传播乙肝病毒的可能性,核酸检测和乙肝核心抗体对献血者OBI筛查具有重要意义,应根据当地HBV流行状况和经济情况选择合适的检测方式,以期最大限度降低OBI对输血安全的影响。
Occult hepatitis B virus infection(OBI)is a special type of hepatitis B virus(HBV)infection in which the hepatitis B surface antigen(HBsAg)test is negative but the HBV nucleic acid test is positive.This article provides a review of the prevalence of OBI among blood donors,the likelihood of transmission,and recommendations of detection.The prevalence of OBI in blood donors varies between some countries in the world and representative regions in China.The analysis showed that the prevalence of OBI in blood donors is much higher in Africa than in the rest of the world,and the prevalence of OBI is higher among blood donors in the south of China than in the north.Blood donor with OBI has the possibility of transmitting HBV.Nucleic acid testing and hepatitis B core antibody detection are important in OBI screening for blood donors,and appropriate testing method should be selected according to the local HBV prevalence and economic situation,in order to minimise the impact of OBI on blood transfusion safety.
作者
孙可望
黄象艳
Sun Kewang;Huang Xiangyan(School of Medical Laboratory,Weifang Medical College,Weifang 261041,China;Department of Transfusion Medicine,The 960th Hospital of the PLA Joint Logistics Support Force,Jinan 250031,China)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2022年第6期753-756,F0003,共5页
Chinese Journal of Experimental and Clinical Virology
基金
山东省自然科学基金(ZR2020MH325)。
关键词
献血者隐匿性乙肝病毒感染
流行率
核心抗体检测
核酸检测
Occult hepatitis B virus infection in blood donors
prevalence
core antibody test
nucleic acid test
