摘要
目的探讨滋阴凉血汤对气阴两虚血瘀证慢性肾炎患者的炎症因子以及相关尿足细胞标记蛋白的干预作用。方法选取2019年1月~2021年9月在上海市中医医院肾内科确诊为慢性肾小球肾炎的患者53例为研究对象,将患者随机分为治疗组(28例)和对照组(25例)。所有患者均给予基础治疗,对照组在此基础上给予厄贝沙坦片150 mg口服,治疗组在对照组基础上给予滋阴凉血汤剂。观察两组治疗前后的中医证候积分及24 h尿蛋白定量(24 h UPro)、尿白蛋白/尿肌酐、肾功能、肿瘤坏死因子-α(TNF-α)、糖萼蛋白(PCX)、肾病蛋白(Nephrin)、肾小球足细胞裂隙膜蛋白(Podocin)。结果两组患者治疗前后24 h-UPro、尿白蛋白/尿肌酐组内比较,差异均有统计学意义(P<0.05);两组治疗前后24 h-UPro、尿白蛋白/尿肌酐组间比较差异无统计学意义(均P>0.05)。两组患者治疗前后TNF-α组内、组间比较,差异均有统计学意义(P<0.05)。治疗组尿PCX治疗前后比较,差异有统计学意义(P<0.01),对照组尿PCX治疗前后组间比较,差异无统计学意义(P=0.188);治疗组与对照组尿PCX治疗前后组间比较,差异均有统计学意义(P<0.01)。两组患者尿Nephrin、尿Podocin治疗前后组内、组间比较,差异均有统计学意义(P<0.05)。两组患者治疗前后中医症候积分组内及组间比较,差异均有统计学意义(P<0.01)。临床观察过程中,治疗组和对照组均未发生不良反应事件。结论与对照组相比,服用滋阴凉血汤的治疗组能更好的减轻慢性肾炎患者的相关症状,改善患者的免疫炎症损伤及肾小球足细胞损伤,从而达到降低蛋白尿、延缓疾病进展的目的。
Objective To observe the intervention effect of Ziyin Liangxue Decoction on inflammatory factors and related podocyte marker proteins in chronic nephritis patients with Qi-yin deficiency and blood stasis syndrome,laying a good foundation for further study of its therapeutic mechanism and pathway.Methods Fifty-three patients diagnosed with chronic glomerulonephritis in the Department of Nephrology,Shanghai Hospital of Traditional Chinese Medicine from January 2019 to September 2021 were selected as the study objects,and the patients were randomly divided into a treatment group(28 cases)and a control group(25 cases).All patients were given basic treatment,control group was additionally given irbesartan tablets 150 mg orally,and treatment group was additionally given nourishing Yin and cooling blood decoction.The TCM syndrome integral and 24 h urine protein quantitative UPro(24 h),urinary albumin/uric creatinine and kidney function,tumor necrosis factor-alpha(TNF-alpha)protein,sugar,calyx(PCX)protein(Nephrin),kidney disease,glomerular podocyte fissure membrane protein(Podocin)were observed.Results 24 h-UPro,urine albumin/uric creatinine of the two groups before treatment were significantly different from that of 24 h-UPro,urine albumin/uric creatinine of the two groups after treatment(P<0.05).24 h-UPro,urine albumin/uric creatinine before and after treatment of treatment group were not significantly different from that of control group(P>0.05).TNF-αbefore and after treatment of the two groups were significantly different(P<0.05).PCX of treatment group after treatment was different from that of before treatment(P<0.05).PCX of control group after treatment was not different from that of before treatment(P>0.05).PCX after treatment of treatment group was different from that of control group(P<0.05).Urinary Nephrin and Podocin of the two group before and after treatment were significantly different(P<0.05).TCM symptom integral of the two group before and after treatment were significantly different(P<0.05).In the cours
作者
王骞
龚学忠
陈丽雯
陈陵
李同路
张威
袁喆平
陶灵佳
WANG Qian;GONG Xuezhong;CHEN Liwen;CHEN Ling;LI Tonglu;ZHANG Wei;YUAN Zheping;TAO Lingjia(Department of Nephrology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)
出处
《西部医学》
2023年第2期208-213,共6页
Medical Journal of West China
基金
上海市卫健委中医临床专项课题(20184Y0207)
上海市中医医院第二批传承项目
上海市中医医院育苗计划。
关键词
慢性肾小球肾炎
滋阴凉血汤
尿足细胞
炎症因子
Chronic glomerulonephritis
Ziyin Liangxue Decoction
Urinary podocyte
Inflammatory cytokines
