摘要
本研究探讨超声造影(CEUS)方法在克罗恩病(CD)患者病情诊断中的临床应用价值。选取经肠镜检查确诊的123例克罗恩病患者作为研究对象,其中包括89例活动期患者和34例缓解期患者。所有患者均行超声及CEUS检查,比较两组患者的肠壁厚度、肠壁血流Limberg分级及CEUS定量分析参数:上升时间(RT)、峰值强度(PI)、达峰时间(TTP)。89例活动期患者的肠壁厚度值显著大于缓解期患者(P<0.05)。活动期患者的肠壁血流Limberg分级分布显著高于缓解期患者(P<0.05)。活动期患者的PI值显著大于缓解期患者(P<0.05),RT值、TTP值显著低于缓解期患者(P<0.05)。重度、中度、轻度活动期患者的肠壁厚度测定值比较,差异均无统计学意义(P>0.05);重度活动期患者的肠壁血流Limberg分级分布高于轻度、中度活动期患者(P<0.05)。重度活动期患者的PI值显著大于轻度、中度活动期患者(P<0.05),RT值、TTP值显著低于轻度、中度活动期患者(P<0.05)。PI、RT、TTP诊断克罗恩病患者缓解期与活动期的AUC值分别为0.852、0.711、0.746。CEUS检查在克罗恩病患者疾病病情及疾病活动程度判断中具有较高的临床应用价值。
This study investigated the clinical value of contrast-enhanced ultrasound(CEUS)in the diagnosis of Crohn’s disease(CD).123 patients with Crohn’s disease diagnosed by colonoscopy were selected as the research objects,including 89 patients in active stage and 34 patients in remission stage.All patients underwent ultrasound and CEUS examination.The intestinal wall thickness,Limberg classification of intestinal wall blood flow and CEUS quantitative analysis parameters[rise time(RT),peak intensity(PI),time to peak(TTP)]were compared between the two groups.The intestinal wall thickness of 89 patients in active stage was significantly higher than that of patients in remission stage(P<0.05).The Limberg grade distribution of intestinal wall blood flow in active patients was higher than that in remission patients(P<0.05).The PI value of active stage patients was significantly higher than that of remission stage patients(P<0.05),and RT value and TTP value were significantly lower than those of remission stage patients(P<0.05).There was no significant difference in intestinal wall thickness between patients with severe,moderate and mild activity(P>0.05).The Limberg grade distribution of intestinal wall blood flow in patients with severe activity was higher than that in patients with mild and moderate activity(P<0.05).The PI value of patients with severe activity was significantly higher than that of patients with mild and moderate activity(P<0.05),and the RT and TTP value were significantly lower than those of patients with mild and moderate activity(P<0.05).The AUC values of PI,RT and TTP in the diagnosis of Crohn’s disease in remission and active phase were 0.852,0.711 and 0.746,respectively.CEUS examination has high clinical application value in the judgment of disease condition and disease activity degree of Crohn’s disease patients.
作者
叶小利
彭永记
朱加成
YE Xiaoli;PENG Yongji;ZHU Jiacheng(Department of General Surgery,Huangshan Shoukang Hospital,Huangshan 245200,Anhui,P.R.China)
出处
《影像科学与光化学》
CAS
北大核心
2023年第1期28-32,共5页
Imaging Science and Photochemistry
关键词
超声造影
克罗恩病
Limberg分级
定量分析
contrast-enhanced ultrasound
Crohn’s disease
Limberg classification
quantitative analysis
