摘要
目的 分析血清抗苗勒管激素(AMH)、人绒毛膜促性腺激素(β-HCG)联合卵泡输出率(FORT)在高龄不孕女性体外受精-胚胎移植(IVF-ET)妊娠结局中的预测价值。方法 收集2021年3月至2022年3月在衡水市人民医院行IVF-ET治疗不孕女性114例,根据其获卵数分亚组:低反应组(获卵数≤3个)38例、正常反应组(获卵数4~15个)49例,高反应组(获卵数≥16个)27例。对比卵巢反应不同者AMH、β-HCG、FORT值;收集不同妊娠结局患者一般资料,分析影响妊娠结局相关因素;分析血清AMH、β-HCG联合FORT对患者妊娠结局预测价值。结果 卵巢反应不同者中AMH、β-HCG、FORT值均为高反应组>正常反应组>低反应组,差异均有统计学意义(P<0.05);非正常妊娠组移植胚胎数、LH/FSH、AMH、β-HCG、FORT均低于正常妊娠组,年龄、Gn用量均高于正常妊娠组,差异均有统计学意义(P<0.05),两组在不孕病程、不孕类型、窦卵泡数、受精率、优质胚胎数、获卵总个数中比较差异无统计学意义(P>0.05);经Logistic回归分析显示,年龄、LH/FSH、Gn用量、移植胚胎数、LH/FSH、AMH、β-HCG、FORT为影响妊娠结局的相关因素(P<0.05);ROC结果显示,AMH、β-HCG、FORT联合检测对妊娠结局预测ACU为0.798(95%CI:0.648~0.898)明显高于三者单独诊断(P<0.05)。结论 AMH、β-HCG、FORT可作为高龄不孕女性IVF-ET妊娠结局预测的重要参考指标,三者联合预测效能更佳,可为预防及降低不良妊娠结局提供参考。
Objective To analyze the predictive value of serum anti-Müllerian hormone(AMH),human chorionic gonadotropin(β-HCG)combined with follicle output rate(FORT)in pregnancy outcomes of in vitro fertilization embryo transfer(IVF-ET)in elderly infertile women. Methods 114 infertile women who underwent IVF-ET in our hospital from March 2021 to March 2022 were collected,and were divided into subgroups according to the number of oocytes retrieved:38 cases in the low response group(the number of oocytes retrieved ≤3),49 cases in the normal response group(the number of oocytes retrieved 4-15),and 27cases in the high response group(the number of oocytes retrieved ≥16). The values of AMH,β-HCG and FORT in patients with different ovarian responses were compared;the general data of patients with different pregnancy outcomes were collected,and the related factors affecting pregnancy outcome were analyzed;the predictive value of serum AMH,β-HCG combined with FORT on pregnancy outcome of patients was analyzed.Results The values of AMH,β-HCG and FORT in the women with different ovarian responses were all that the high response group > the normal response group > the low response group,and the differences were statistically significant(P<0.05). The number of transferred embryos,LH/FSH,AMH,β-HCG,and FORT in the abnormal pregnancy group were lower than those in the normal pregnancy group,and the age and Gn dosage were higher than those in the normal pregnancy group,and the differences were statistically significant(P<0.05). There was no significant difference in the duration of infertility,infertility type,the number of antral follicles,fertilization rate,number of high-quality embryos,and total number of eggs retrieved between the two groups(P>0.05). Logistic regression analysis showed that age,LH/FSH,Gn dosage,number of transferred embryos,LH/FSH,AMH,β-HCG,and FORT were the related factors affecting pregnancy outcome(P<0.05).The ROC results showed that the ACU of the combined detection of AMH,β-HCG and FORT to predict preg
作者
张淑贞
王磊
张敬
ZHANG Shuzhen;WANG Lei;ZHANG Jing(Department of Reproductive Medicine,Hengshui People's Hospital,Hengshui,Hebei,China,053000)
出处
《分子诊断与治疗杂志》
2022年第11期1954-1958,共5页
Journal of Molecular Diagnostics and Therapy
基金
衡水市科技计划项目(2018014004Z)。
关键词
高龄不孕
体外受精-胚胎移植
妊娠结局
Infertility in advanced age
In vitro fertilization-embryo transfer
Pregnancy outcome
