摘要
目的探究体外受精-胚胎移植(IVF-ET)患者卵泡输出率(FORT)与卵巢反应性及治疗结局的相关性。方法回顾性分析湖北省妇幼保健院124例经IVF-ET治疗患者临床资料,根据患者FORT三分位数分为低FORT组、中FORT组及高FORT组,记录3组基线资料、卵巢反应性及IVF-ET治疗情况;124例患者(中行胚胎移植患者89例)根据临床妊娠情况分为妊娠组及非妊娠组,比较其FORT差异,使用受试者工作曲线(ROC)评估FORT对IVF-ET治疗结局的预测价值。结果根据FORT三分位数P25、P75分为FORT<56%组(低FORT组,n=39)、56%≤FORT≤80%组(中FORT组,n=48)及FORT>80%组(高FORT组,n=37);3组年龄、BMI、不孕时间、IVF-ET适应证等基线资料比较,差异无统计学意义(P>0.05)。3组Gn总量、Gn总时间及移植周期取消率、流产率比较,差异无统计学意义(P>0.05);3组HCG日E2、获卵数、受精率、卵裂率、优质胚胎率、临床妊娠率、中重度OHSS比较,均为低FORT组<中FORT组<高FORT组,差异有统计学意义(P<0.05)。妊娠组47例患者FORT为(68.39±7.48)%,非妊娠组42例患者FORT为(56.52±9.67)%,妊娠组FORT明显高于非妊娠组,差异有统计学意义(P<0.05)。经ROC曲线分析,发现FORT对IVF-ET治疗临床妊娠具有较高预测价值(AUC=0.826,P<0.05),其Cut-off值为61.73%。结论FORT能评估IVF-ET患者卵巢反应性,并辅助预测治疗结局,应用价值显著。
Objective To explore the correlation between follicular output rate(FORT)and ovarian reactivity and treatment outcomes in patients with in vitro fertilization-embryo transfer(IVF-ET).Methods The clinical data of 124 patients treated with IVF-ET in Hubei Maternal and Child Health Hospital were retrospectively analyzed.The patients were divided into low FORT group,middle FORT group and high FORT group according to the FORT tertiles.Baseline data,ovarian reactivity and IVF-ET treatment were recorded among the three groups.89 patients with embryo transplantation among 124 patients were divided into pregnant group and non-pregnant group according to the clinical pregnancy,and FORT difference was compared,and receiver operating characteristic curve(ROC curve)was used to evaluate the predictive value of FORT on IVF-ET treatment outcomes.Results According to FORT tertiles P25 and P75,the patients were divided into FORT<56% group(low FORT group,n=39),56%≤FORT≤80% group(middle FORT group,n=48)and FORT>80% group(high FORT group,n=37).There were no statistically significant differences in the baseline data such as age,BMI,infertility time and IVF-ET indications among the three groups(P>0.05).There were no statistically significant differences in total Gn,total Gn time,cycle cancellation rate and abortion rate among the three groups(P>0.05).Comparison of E2 on the day of HCG,number of retrieved oocytes,fertilization rate,cleavage rate,high-quality embryo rate,clinical pregnancy rate,moderate and severe OHSS rate showed that low FORT group<middle FORT group<high FORT group(P<0.05).The FORT of 47 patients in pregnant group was(68.39±7.48)%,and the FORT of 42 patients in non-pregnant group was(56.52±9.67)%.The FORT in pregnant group was significantly higher than that in non-pregnant group(P<0.05).Through ROC curve analysis,it is found that FORT had a high predictive value on IVF-ET treatment of clinical pregnancy(AUC=0.826,P<0.05),and its Cut-off value was 61.73%.Conclusion FORT can evaluate ovarian reactivity in patients
作者
陈碧娟
杨萍
刘文婷
CHEN Bi-juan;YANG Ping;LIU Wen-ting(Department of Reproductive Medicine,Hubei Maternal and Child Health Hospital,Wuhan Hubei 430070,China)
出处
《临床和实验医学杂志》
2020年第22期2438-2441,共4页
Journal of Clinical and Experimental Medicine
基金
湖北省自然科学基金项目(No.2015CFA100)。
关键词
体外受精-胚胎移植
卵泡输出率
卵巢反应性
临床妊娠
In vitro fertilization-embryo transfer
Follicular output rate
Ovarian reactivity
Clinical pregnancy
