摘要
目的探讨贺斯与白蛋白在预防重度卵巢过度刺激综合征(OHSS)中的作用。方法应用前瞻性随机研究将OHSS高危患者分为3组,Ⅰ组47例,Ⅱ组46例,于取卵后分别静点白蛋白20g、贺斯1000ml作为预防性治疗组,Ⅲ组57例未予任何治疗作为对照组,监测用药前后卵巢大小变化与腹水深度,观察各组治疗后的可移植人数、移植胚胎数、妊娠人数及发生重度OHSS的患者人数。结果3组患者移植人数、移植胚胎数、妊娠人数、重度OHSS发生人数差异均无显著性(P>0.05),其中重度OHSS发病率在对照组最高;贺斯组的移植日与hCG日卵巢大小差值较其他两组为低,差异无显著性(P>0.05)。结论预防性应用贺斯与白蛋白并不能避免重度OHSS的发生,但对降低OHSS的发病率有一定作用。
Objective To compare the efficacy of hydroxyethyl starch （HES） and human albumin for prevention of the ovarian hyperstimulation syndrome （OHSS）. Methods A prospective, randomized and placebo - controlled study was conducted to assess the effectiveness of intravenous of 6% HES, human albumin at the time of oocyte retrieval in preventing severe OHSS in high - risk patients in an invitro fertilization programme. There were 47 patients in human albumin group, 46 in HES group, and 57 in control group without treatment. The ovarian size was measured on the day of hCG administration, oocyte collection and embryo transfer. The number of transferred patients, embryos transferred, pregnancies and severe OHSS patients were observed in the study. Results No significant difference of the number of transferred patients, embryos transferred, pregnancies and severe OHSS patients was found in the three groups （P〉0. 05）. The number of severe OHSS patients in control group was higher than that in the other groups. Although there was no significant difference of the ovarian enlargement in three groups on the day of embryo transfer and on the day of hCG administration （P〉0.05）, it was lower in HES group than that in the other groups. Conclusion Administration of HES and albumin did not avoid the development of severe OHSS in high - risk patients, but infused treatment of colloid may help in reducing the incidence of severe OHSS.
出处
《中国妇产科临床杂志》
2007年第4期245-248,299,共5页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
贺斯
白蛋白
卵巢过度刺激综合征
预防
hydroxyethyl starch
human albumin
ovarian hyperstimulation syndrome
prevention
