摘要
目的评价开郁苦泄法治疗气郁痰阻型新诊断超重2型糖尿病患者的临床疗效。方法研究纳入新诊断2型糖尿患者100例,随机分为治疗组和对照组各50例,在生活方式干预下,治疗组口服甘松降糖颗粒9 g/次,3次/日,对照组口服二甲双胍500 mg/次,3次/日,共观察12周,记录两组血糖、HbA1c、HOMA指数及脂代谢指标等统计分析。结果(1)研究完成可评价样本83例,治疗组43例,对照组40例,治疗组和对照组HbA1c分别下降1.14%和1.34%,FBG降低1.93 mmol·L^(-1)和2.23 mmol·L^(-1),2 h BG降低5.72 mmol·L^(-1)和6.56 mmol·L^(-1),组内比较差异均有统计学意义(P<0.01),组间比较差异无统计学意义(P>0.05)。(2)胰岛素释放试验结果显示两组各时段血糖均较前明显下降(P<0.05),且1 h PG治疗组下降优于对照组(P<0.05),治疗组1 h INS升高优于对照组(P<0.05),两组3 h INS均较前降低(P<0.05),组间比较差异无统计学意义(P>0.05)。(3)两组治疗后体重、腰围、BMI下降均有统计学意义(P<0.01),治疗组TC和对照组LDL-C下降有统计学意义(P<0.05),组间比较差异均无统计学意义(P>0.05)。(4)两组HOMA-IR和ISI均明显改善(P<0.01),组间比较无差异(P>0.05),两组HOMA-β较治疗前变化无统计学意义(P>0.05),但组间比较治疗组改善优于对照组(P<0.01)。(5)两组证候疗效比较治疗组总有效率90.70%,对照组77.50%,治疗组明显优于对照组(P<0.01)。结论开郁苦泄法治疗新诊断超重2型糖尿病(气郁痰阻型)在控制血糖、减轻体重、改善胰岛素抵抗、调节血脂方面疗效与二甲双胍相当,并能显著改善患者中医证候。
Objective To evaluate the clinical efficacy of the method of Kaiyu Kuxie in the treatment of newly overweight type 2 diabetes patients with Qi stagnation and phlegm stagnation.Methods 100 newly diagnosed type 2 diabetes patients were enrolled in the study,and randomly divided into the treatment group and the control group,50 patients in each group.Under the intervention of lifestyle,the treatment group took orally the Gansong Jiangtang Granules 9 g/time,3 times/day,and the control group took orally the metformin 500 mg/time,3 times/day.A total of 12 weeks were observed,and the blood glucose,HbA1c,HOMA index and lipid metabolism indexes of the two groups were recorded for statistical analysis.Results(1)There were 83 evaluable samples after the study,43 in the treatment group and 40 in the control group.HbA1c in the treatment group and the control group decreased by 1.14%and 1.34%,FBG decreased by 1.93mmol·L^(-1)and 2.23 mmol·L^(-1),and BG decreased by 5.72 mmol·L^(-1)and 6.56mmol/L at 2h.There were significant differences within the group(P<0.01),but no significant differences between the groups(P>0.05).(2)The results of insulin release test showed that the blood glucose of the two groups in each period was significantly lower than before(P<0.05),and the decrease in the 1h PG treatment group was better than that in the control group(P<0.05),the increase in the 1h INS of the treatment group was better than that in the control group(P<0.05),and the 3h INS of the two groups was lower than before(P<0.05),and there was no significant difference between the two groups(P>0.05).(3)The weight,waist circumference and BMI of the two groups decreased significantly after treatment(P<0.01).The decrease of LDL-C in the treatment group and the control group was statistically significant(P<0.05),and there was no significant difference between the two groups(P>0.05).(4)HOMA-IR and ISI in the two groups were significantly improved(P<0.01),and there was no difference between the two groups(P>0.05).HOMA-βin the two groups had no s
作者
张恒耀
纪少秀
汪燕燕
魏彦宁
颜青
毕然
党毓起
ZHANG Hengyao;JI Shaoxiu;WANG Yanyan;WEI Yanning;YAN Qing;BI Ran;DANG Yuqi(Yinchuan Traditional Chinese Medicine Hospital,Yinchuan 750001,China;Ningxia Metabolic Disease(Integrated Traditional and Western Medicine)Clinical Medical Research Center,Yinchuan 750001,China)
出处
《陕西中医药大学学报》
2023年第1期48-54,共7页
Journal of Shaanxi University of Chinese Medicine
基金
宁夏自然科学基金项目(2019AAC03280)
宁夏青年科技人才托举工程项目(TJGC2019097)
银川市科技创新重点专项(2021-SF-002)。
关键词
开郁苦泄
超重
新诊断2型糖尿病
气郁痰阻
中医治疗
Kaiku Kuxie
Overweight
New type 2 diabetes
Qi stagnation and phlegm obstruction
TCM treatment
