摘要
目的探讨腰高比(WHtR)与超重2型糖尿病(T2DM)视网膜病变(DR)的相关性。方法招募2019年11月至2020年8月在郑州大学附属洛阳中心医院内分泌科收治的符合条件的620例超重T2DM者,进行回顾性横断面研究,根据是否合并DR分为单纯超重T2DM组和超重T2DM合并DR组,并收集其一般资料及临床指标等,组间比较用t检验,计数资料组间比较用卡方检验;通过统计学分析WHtR与超重DR的相关性。结果单纯超重T2DM组男282例,女137例,共419例,占总例数67.6%;超重T2DM合并DR组男104例,女97例,共201例,占总例数32.4%。与单纯超重T2DM组相比,超重T2DM合并DR组男性比例更高(P<0.001),相对更高的身高(P=0.001)、体质量指数(P=0.023),更大的腰围(P=0.001)、臀围(P=0.011)、WHtR(P<0.001),糖尿病病程相对更长(P<0.001),更高的糖化血红蛋白(P<0.001),高血压病的发生率更高(P<0.001)。将单因素中有意义的指标纳入多因素logistic分析模型中,结果提示:性别[比值比(OR):0.566,95%置信区间(CI):0.331~0.969,P=0.038)、身高(OR:0.933,95%CI:0.913~0.952,P<0.001)、腰围(OR:1.163,95%CI:1.083~1.249,P<0.001)、WHtR(OR:1.074,95%CI:1.063~1.857,P=0.007)、糖尿病病程(OR:1.056;95%CI:1.027~1.087,P<0.001)、糖化血红蛋白(OR:1.560,95%CI:1.391~1.749,P<0.001)、高血压病(OR:1.478,95%CI:1.323~1.707,P<0.001)可能是超重DR的相关危险因素。结论WHtR与超重DR具有相关性。
Objective To assess the correlation between waist-to-height ratio(WHtR)and diabetic retinopathy(DR)in over-weight patients with type 2 diabetes mellitus(T2DM).Methods A total of 620 over-weight patients with T2DM treated at Department of Endocrinology,Luoyang Central Hospital Affiliated to Zhengzhou University from November 2019 August 2020 were included for a retrospective cross-sectional study.According to whether they were complicated with DR,the patients were divided into an over-weight T2DM group and an over-weight T2DM combined with DR group.Their general data and clinical indicators were collected.The t test was used for the comparison between the two groups,and the chi-square test was used for the comparison of count data between the two groups.The correlation between WHtR and DR in the over-weight patients with T2DM were statistically analyzed.Results There were 419 cases(67.6%)in the over-weight T2DM group,including 282 males and 137 females;there were 201 cases(32.4%)in the over-weight T2DM combined with DR group,including 104 males and 97 females.Compared with the over-weight T2DM group,the over-weight T2DM combined with DR group had a higher proportion of men(P<0.001),relatively higher height(P=0.001),higher body mass index(BMI)(P=0.023),larger waist circumference(P=0.001),larger hip circumference(P=0.011),higher WHtR(P<0.001),relatively longer duration of T2DM(P<0.001),higher HbA1c(P<0.001),and a higher incidence of hypertension(P<0.001).The multivariate logistic regression analysis showed that gender(OR=0.566,95%CI 0.331-0.969,P=0.038),height(OR=0.933,95%CI 0.913-0.952,P<0.001),waist circumference(OR=1.163,95%CI 1.083-1.249,P<0.001),WHtR(OR=1.074,95%CI 1.063-1.857,P=0.007),T2DM course(OR=1.056,95%CI 1.027-1.087,P<0.001),HbA1c(OR=1.560,95%CI 1.391-1.749,P<0.001),hypertension(OR=1.478,95%CI 1.323-1.707,P<0.001)might be the associated risk factors with DR in the over-weight patients with T2DM.Conclusion WHtR is associated with DR in over-weight patients with T2DM.
作者
黄珂
石守森
张艳芳
Huang Ke;Shi Shousen;Zhang Yanfang(Department of Endocrinology,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China;Department of Gastrointestinal Surgery,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)
出处
《国际医药卫生导报》
2022年第9期1195-1199,共5页
International Medicine and Health Guidance News
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200873)
河南省医学科技攻关项目(212102310193)。
关键词
腰高比
2型糖尿病
视网膜病变
超重
危险因素
Waist-to-height ratio
Type 2 diabetes mellitus
Retinopathy
Over-weight
Risk factors
