摘要
氯胺酮是一种非选择性N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid,NMDA)受体拮抗剂,近年来氯胺酮在神经精神疾病的治疗和研究中的地位举足轻重。氯胺酮拟精神作用和奖励通路的神经机制目前仍待完善,可能与大脑内多种神经元及通路密切相关,本文将对目前国内外相关研究进行综述并尝试整合已知的神经机制以及提出合理的假设。
Ketamine is a non-selective N-methyl-D-aspartic acid(NMDA)receptor antagonist.Ketamine plays a significant role in the treatment and research of neuropsychiatric diseases in recent years.The neural mechanism of ketamine psychogenic effects and reward pathway remains to be perfected,which may be closely related to a variety of neurons and pathways in the brain.This paper intends to review the relevant studies at home and abroad,and try to integrate the known neural mechanisms and put forward reasonable hypotheses.
作者
杨航
陆方舟
杨春
朱伟
YANG Hang;LU Fangzhou;YANG Chun;ZHU Wei(The First Clinical College of Medicine,Nanjing Medical University,Nanjing 211166,Jiangsu,China;Department of Anesthesia and Perioperative Medicine,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2022年第12期1347-1353,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金(82271254)。
关键词
氯胺酮
拟精神症状
奖励
神经机制
药物依赖
ketamine
psychomimetic symptoms
reward
neural mechanism
drug dependence
