摘要
认知功能损害已成为影响老年患者生活质量的重要因素。现有的研究尚不能回答是何种因素引起认知功能减退,不少学者认为麻醉与镇痛药物可能在认知功能障碍中扮演重要角色。本综述将探讨不同麻醉镇痛药对认知功能的影响并简要叙述其机制,为临床合理选择用药方案提供参考。
Cognitive dysfunction has become a pivotal factor affecting the quality of life of elderly patients.The existing literatures can not explain the factors causing cognitive decline.Many researchers believe that anesthetics and analgesics may play important roles in cognitive dysfunction.This review will discuss the effects of different anesthetics and analgesics on cognitive function and briefly describe their mechanisms,so as to provide reference for the rational choice of medications in clinical practice.
作者
倪渊博
张昕
李仪
刘存明
NI Yuanbo;ZHANG Xin;LI Yi;LIU Cunming(Nanjing Medical University,Nanjing 210000,Jiangsu,China;Department of Anesthesiology and Perioperative Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210000,Jiangsu,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2022年第12期1365-1374,共10页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
江苏省自然科学基金面上项目(BK20211382)。
关键词
认知功能障碍
全身麻醉
静脉麻醉药
阿片类药物
吸入麻醉药
cognitive dysfunction
general anesthesia
intravenous anesthetics
opioids
inhaled anesthetics
