摘要
超抗原是一类由细菌、病毒等产生的具有强丝裂原活性的外毒素,与主要组织相容性复合体Ⅱ结合,刺激T细胞产生并释放大量的促炎细胞因子,在极低浓度下即可刺激机体产生超强免疫应答,是迄今发现的最有效的T细胞丝裂原。链球菌超抗原在链球菌感染致病过程中发挥重要作用,可促进链球菌的定植、增殖和传播。深入研究链球菌超抗原生物学特性对了解链球菌致病机制、预防和治疗链球菌感染具有重要意义。本文主要探讨链球菌超抗原的分类及特点、致病机制与开发应用等相关研究进展,为临床认识和深入研究相关疾病提供参考。
Superantigens are highly mitogenic exotoxins produced by bacteria and viruses.They can bind to the major histocompatibility complex classⅡ,stimulate T cell receptor molecules to release a large quantity of proinflammatory cytokines,and activate the immune system in vastly low concentrations.Superantigens have been the most effective T cell mitogen discovered so far.Superantigens play important roles in infection diseases caused by streptococcal pathogens,and they can facilitate pathogen colonization,proliferation,and dissemination.Further research of biological chara-cteristics of streptococcus superantigens is vital to understanding the streptococcus pathogenesis,prevention and treatment of streptococcus infection.In this article,advances in the classification,biological properties,pathogenesis,deve-lopment and application of streptococcal superantigens were reviewed,so as to improve the clinical understanding and provide reference for in-depth research of related diseases.
作者
董立民
姚开虎
Dong Limin;Yao Kaihu(Key Laboratory of Major Diseases in Children,Ministry of Education,National Key Discipline of Pediatrics(Capital Medical University),Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2022年第21期1674-1677,共4页
Chinese Journal of Applied Clinical Pediatrics
基金
兵团财政科技计划项目南疆重点产业创新发展支撑计划(2021DB020)。
关键词
超抗原
链球菌
生物学特性
致病机制
Superantigen
Streptococcus
Biological properties
Pathogenesis
