摘要
巨噬细胞活化脂肽-2(MALP-2)是发酵支原体(Mf)上极具代表性的外膜脂肽,N端为特殊的二酰化半胱氨酸残基结构。MALP-2是一把"双刃剑",在致炎与抗炎、细胞凋亡与抗凋亡、免疫佐剂、生物协同与抑制、血管损伤和血管修复等方面发挥重要作用。因此,了解MALP-2复杂的生物学作用能为理解Mf的致病机制及其临床治疗方案提供依据,同时也为MALP-2的临床应用提供理论基础。
Macrophage-activating lipopeptide-2(MALP-2)is a classical mycoplasma-derived outer membrane lipopeptide on Mycoplasma fermentans(Mf)with a special diacylated cysteine residue structure at the N-terminal.MALP-2 poses as a double-edged sword that plays an important role in inflammation and anti-inflammation,apoptosis and anti-apoptosis,immune adjuvant,biological synergy,biological inhibition,vascular injury and vascular repair,etc.Therefore,making out the complex immunologic mechanisms of MALP-2 can provide a basis for understanding the pathogenesis of Mf and its clinical treatment,which also provides a theoretical basis for the clinical application of MALP-2.
作者
梁珂莹
刘君
曾焱华
何军
LIANG Keying;LIU Jun;ZENG Yanhua;HE Jun(Department of Clinical Laboratory,Nanhua Affiliated Hospital,University of South China,Hengyang 421002,Hunan,China;Institute of Pathogenic Biology,Hengyang Medical College,University of South China,Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control,Hengyang 421001,Hunan,China)
出处
《中南医学科学杂志》
CAS
2020年第5期449-453,共5页
Medical Science Journal of Central South China
基金
国家自然科学基金资助项目(31100137)
湖南省自然科学基金资助项目(2018JJ6072)
湖南省卫生健康委科研重点课题(20201915)。
关键词
发酵支原体
巨噬细胞活化脂肽-2
生物学作用
致病机制
mycoplasma fermentans
macrophage-activating lipopeptide-2
immuno-logic mechanisms
pathogenesis
