摘要
某些链球菌在感染过程中,会引发宿主系统性的细胞因子风暴,病程进展迅速,致死率高,即发生链球菌性中毒性休克综合症(streptococcal toxic shock syndrome,STSS)。最初认为STSS由链球菌的超抗原(superantigen,SAg)引发,但近年来也有不依赖超抗原的STSS病例报道,致病机制较为复杂。本文主要对不依赖链球菌超抗原引发STSS的机制研究进行介绍,包括链球菌感染后宿主细胞中炎症信号通路的激活、炎性小体和细胞焦亡的发生、促炎细胞因子的释放以及细胞因子风暴等。同时,对研究链球菌STSS常采用的细胞和动物模型进行总结,旨在为实验室开展STSS的机制研究奠定理论基础。
Streptococcal toxic shock syndrome(STSS)is a rapidly progressing,life-threatening,systemic reaction to invasive infection caused by streptococci,which is characterized by a cytokine storm in the host.Although the majority of clinical STSS cases are triggered by the superantigens(SAgs),a few STSS cases are not associated with SAgs and the related mechanisms are considered to be complicated.Here,we review the recent research progress on the mechanism of SAgs-independent STSS,including the activation of inflammatory signaling pathways in host triggered by Streptococcus,the activation of inflammatosomes and pyroptosis,the pro-inflammatory cytokines and cytokine storm.We also summarize cell and animal models usually used in STSS research.This review is useful for a better understanding of STSS and provides a theoretical foundation for the research of STSS mechanism.
作者
张郁敏
马家乐
赵焱
刘广锦
Yumin Zhang;Jiale Ma;Yan Zhao;Guangjin Liu(MOE Joint International Research Laboratory of Animal Health and Food Safety,Ministry of Education,Key Laboratory of Animal Bacteriology,Ministry of Agriculture,OIE Reference Laboratory for Swine Streptococcosis,College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,Jiangsu Province,China;State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730030,Gansu Province,China)
出处
《微生物学报》
CAS
CSCD
北大核心
2021年第3期501-511,共11页
Acta Microbiologica Sinica
基金
国家自然科学基金(31502085)
家畜疫病病原生物学国家重点实验室(中国农业科学院兰州兽医研究所)开放课题(SKLVEB2018KFKT011)
中央高校基本科研业务费专项资金(KJQN201618)
江苏省自然科学基金青年项目(BK20180530)
江苏省优势学科项目(PAPD)。
