摘要
目的分析食管癌组织中脆性组氨酸三联体基因(fragilehistidinetriad,FHIT)蛋白及mRNA的表达及临床意义。方法回顾性选取2019年3月~2021年10月赤峰市医院的食管癌患者60例样本为病例组、内镜室的正常食管组织患者60例样本作为对照组。统计分析两组组织中FHIT蛋白及mRNA表达,分析病例组癌组织中FHIT mRNA与临床病理参数的相关性。结果与对照组正常组织相比,病例组癌组织、癌旁组织中FHIT蛋白缺失表达率、弱表达率均较高,正常表达率均较低,差异有统计学意义(P<0.05),而与癌旁组织相比,癌组织中FHIT蛋白缺失表达率较高,弱表达率、正常表达率均较低,差异有统计学意义(P<0.05)。与对照组正常组织相比,病例组癌组织、癌旁组织中FHIT mRNA缺失率均较高,差异有统计学意义(P<0.05),与癌旁组织相比,癌组织中FHIT mRNA缺失率较高,差异有统计学意义(P<0.05)。与Ⅰ期患者相比,病例组Ⅱ+Ⅲ+Ⅳ期患者的FHIT蛋白缺失率及mRNA缺失率较高,差异有统计学意义(P<0.05);与高分化患者相比,低分化、中分化患者的FHIT蛋白缺失率及mRNA缺失率均较高,差异有统计学意义(P<0.05);与无淋巴结转移患者相比,有淋巴结转移患者的FHIT蛋白缺失率及mRNA缺失率较高,差异有统计学意义(P<0.05)。结论FHIT蛋白及mRNA在食管癌组织中的缺失表达率提升,能够为临床诊断与治疗及预后判断提供有效依据。
Objective To analyze the expression and clinical significance of FHIT protein and mRNA in esophageal carcinoma.Methods A total of 60 samples from patients with esophageal cancer in Chifeng Hospital from March 2019 to October 2021 were retrospectively selected as the case group and 60 samples from patients with normal esophageal tissue in the endoscopy room were selected as the control group.The expression of FHIT protein and mRNA in the two groups were statistically analyzed,and the correlation between FHIT mRNA in the case group and clinicopathological parameters was analyzed.Results Compared with the normal tissues of the control group,the deletion and weak expression rates of FHIT protein in the cancer tissues and adjacent tissues of the case group were higher,and the normal expression rates were lower,the diffierence was statistically signicant(P<0.05).Compared with adjacent tissues,the expression rate of FHIT protein deletion in cancer tissues was higher,and the weak and normal expression rates were lower,the diffierence was statistically signicant(P<0.05).Compared with the normal tissue of the control group,the deletion rate of FHIT mRNA in the cancer tissue and paracancerous tissue of the case group was higher,the diffierence was statistically signicant(P<0.05),and compared with the paracancerous tissue,the deletion rate of FHIT mRNA in the cancer tissue was higher,the diffierence was statistically signicant(P<0.05).Compared with patients with stage I,the FHIT protein deletion rate and mRNA deletion rate of patients with stage Ⅱ+Ⅲ+Ⅳ in the case group were higher,the diffierence was statistically signicant(P<0.05).Compared with well-differentiated patients,the expression rate of FHIT protein deletion and mRNA deletion rate were higher in patients with low and medium differentiation,the diffierence was statistically signicant(P<0.05).Compared with patients without lymph node metastasis,the FHIT protein deletion rate and mRNA deletion rate of patients with lymph node metastasis were higher,the diffieren
作者
陈鹏
CHEN Peng(Department of Oncology,Chifeng Hospital,Chifeng Inner Mongolia 024000,China)
出处
《中华养生保健》
2023年第2期9-12,共4页
CHINESE HEALTH CARE
关键词
食管癌
FHIT
蛋白
MRNA
临床病理参数
esophageal carcinoma
FHIT
protein
mRNA
clinicopathological parameters
