摘要
增生平片在食管癌高发区二级预防中，使食管上皮重度增生患者３年和５年癌变率下降约５０％，说明该药是食管癌生成的有效阻断剂。作者选用８项实验指标对增生平片的免疫调节效应和抗促癌作用进行了初步研究。结果表明，增生平片不仅是有效的抗促癌药物，而且具有明显的免疫调节作用。提示食管上皮重增患者癌变率的降低，是本药对机体免疫功能激活作用和抗促癌作用的综合效果。
Abstract Zeng Sheng Pin
Pian (ZSPP)is a mixture of medicinal herbs which has been shown to be effec-tive in the
secondary prevention of esophageal cancer in a high -risk area among a population with severe
esophageal dysplasia. This study in mice aimed at elucidating the possible mechanism ofthe
cancer-preventing activity of ZSPP. The results indicate that ZSPP is a good biologic
responsemodifier (BRM) as shown by its enhancing effects on lymphocyte blastogenesis, IL-2
secretion, NKcell activity, delayed-type hypersensitivity reaction to DNCB, hemolysin response
to SRBC and the phagocytic function of the reticulo-endothelial system. While ZSPP did not
inhibit the growth of S-180 in mice, it exhibited. significant inhibitory effect on ornithine
decarboxylase (ODC)activity in-duced by the application of croton oil to the skin. Taken together,
the immune enhancing activityand the anti-tumor-promoting activity of ZSPP could explain, at
least in part, its efficacy in theprevention of esophageal cancer among high-risk people with
precursor dysplastic lesions.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第6期419-423,共5页
Chinese Journal of Oncology
基金
"七.五"国家医学科技重点项目
