摘要
以廉价易得的吲哚和三氟乙酸酐为原料,经过傅-克酰基化反应合成得到目标化合物3-三氟乙酰基吲哚,其结构经~1H-NMR和ESI-MS表征。对3-三氟乙酰基吲哚的合成工艺进行研究,确定适宜的反应条件为:物料比为n(三氟乙酸酐)∶n(吲哚)=7∶1,过量的三氟乙酸酐在反应过程中不但是反应物,而且起到溶剂的作用,反应温度为25℃,反应时间4h。在该反应条件下,产物收率为87.5%(以吲哚计)。
The target compounds 3-(trifluoroacetyl) indole was synthesized through Friedel-Crafts acylation reaction by using the readily available and cheap starting materials of indole and trifluoroacetic anhydride.The structures of product was characterized by ~1H-NMR and ESI-MS.Also, the synthesis process was studied and the suitable reaction conditions were determined as follows: material ratio n(trifluoroacetic anhydride)∶n(indole)= 7∶1,the excess of trifluoroacetic anhydride not only played the role of reactant, but also regarded as reactive solvent in the synthesis of 3-(trifluoroacetyl) indole.Reaction temperature was 25℃,reaction time 4 h.Under these conditions, the yield of the product was up to 87.5%(calculated based on indole).
作者
张改琴
唐琴
唐华
石洁
张洁
唐文强
ZHANG Gai-qin;TANG Qin;TANG Hua;SHI Jie;ZHANG Jie;TANG Wen-qian(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xianyang 712046,China)
出处
《精细与专用化学品》
CAS
2022年第12期42-44,49,共4页
Fine and Specialty Chemicals
基金
2021年陕西省大学生创新创业训练计划项目(S202113123022)
咸阳市分子影像与药物合成重点实验室项目(2021QXNL-PT-0008)。
关键词
吲哚衍生物
3-三氟乙酰基吲哚
傅-克酰基化反应
合成
indole derivatives
3-(trifluoroacetyl)indole
Friedel-Crafts acylation reaction
synthesis
