摘要
在60℃下,有机底物1-苯丙酮被相转移剂PPNCl溶进水中,被甲酸钠还原成α-乙基苯甲醇的反应,使用了水溶性铱配合物做催化剂;探讨了反应的最佳条件为n_(苯丙酮):n_(甲酸钠):n_(催化剂):n_(相转移剂)=1:4:0.005:0.02;通过高效液相色谱法(HPLC)测试,获得反应的转化率及的产物的对映体过量值e.e.,在最佳反应条件下,转化率为98%,产物对映体过量值e.e.是87%;产物经IR、^(1)H NMR和^(13)C NMR确证结构,分子构型经旋光度测试并与文献报道比对确定为S型。
At 60℃,the water-soluble iridium complex was used as the catalyst,and the organic substrate(S)-1-benzene-1-acetone was dissolved by phase transfer agent PPNCl into the influent phase,and reduced to chiral 1-phenyl-1-propanol by sodium formate.The optimum reaction conditions were as follows:n(phenylacetone):n(formate):n(catalyst):n(phase transfer agent)=1:4:0.005:0.02.High performance liquid chromatography(HPLC)was used to test the reaction conversion rate and the enantiomer overvalue of the product E.E.Under the best reaction conditions,the conversion rate was 98%,the enantiomer overvalue of the product e.e.was 87%.The structure of the product was confirmed by IR,^(1)H NMR and ^(13)C NMR,and the molecular configuration was determined as S-type by spectrophotometry test and compared with literature reports.
作者
郭庆君
GUO Qing-jun(College of Chemistry&Chemicaland Materials,Jining University,Shandong Qufu 273155,China)
出处
《广州化工》
CAS
2022年第10期18-21,43,共5页
GuangZhou Chemical Industry
关键词
合成
不对称催化
手性
旋光
synthesis
asymmetric catalysis
chiral
optical activity
