摘要
The synthesis of(S)-1-phenyl-1,2-ethanediol was studied in this article.Firstly,1,2-dibromo-1-phenylethane was synthesized with styrene and bromine as starting agents.The effects of some factors,including raw materials’ molar ratio,reaction time and solvents,on the yield of 1,2-dibromo-1-phenylethane were examined.Secondly,1-phenyl-1,2-ethanediol was obtained by use of hydrolysis of 1,2-dibromo-1-phenylethane in alkaline medium.The influence of reaction time and medium on the yield of 1-phenyl-1,2-ethanediol was also examined.Under the optimized conditions,the yield of 1,2-dibromo-1-phenylethane was 90.1% while the yield of 1-phenyl-1,2-ethanediol was 78.5%.Finally,(S)-1-phenyl-1,2-ethanediol was received by deracemization of 1-phenyl-1,2-ethanediol employing Candida parapsilosis.The enantiomeric excess of(S)-1-phenyl-1,2-ethanediol was 99% and the conversion was 88%.
The synthesis of（S）-1-phenyl-1,2-ethanediol was studied in this article. Firstly, 1,2-dibromo-1-phenylethane was synthesized with styrene and bromine as starting agents. The effects of some factors, including raw materials＇ molar ratio, reaction time and solvents, on the yield of 1 ,2-dibromo-1-phenylethane were examined. Secondly, 1-phenyl-1,2-ethanediol was obtained by use of hydrolysis of 1,2-dibromo-1 -phenylethane in alkaline medium. The influence of reaction time and medium on the yield of 1-phenyl-1, 2-ethanedlol was also examined. Under the optimized conditions, the yield of 1,2-dibromo-l-phenylethane was 90. 1% while the yield of 1-phenyl-1,2-ethanediol was 78.5%. Finally, （S） -1 -phenyl-1 ,2-ethanediol was received by deracemization of 1-phenyl-1, 2-ethanediol employing Candida parapsilosis. The enantiomeric excess of（ S） -1 -phenyl-1,2-ethanediol was 99% and the conversion was 88%.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2009年第10期1435-1438,共4页
Chemical Research and Application
基金
国家863计划(2006AA10Z310)资助项目
华东理工大学生物反应器工程国家重点实验室开放课题资助项目
