摘要
目的:观察替格瑞洛在颅内动脉瘤支架辅助栓塞手术后氯吡格雷抵抗患者中的应用效果。方法:选取2015年1月—2021年12月乳山市人民医院收治的104例颅内动脉瘤行支架辅助栓塞术后氯吡格雷抵抗患者,采用随机数字表法分为对比组与实验组各52例。对比组采取氯吡格雷联合阿司匹林用于抗血小板治疗,实验组采用替格瑞洛联合阿司匹林用于抗血小板治疗,比较两组的治疗效果。结果:实验组治疗总有效率高于对比组,差异有统计学意义(P<0.05);不良反应总发生率低于对比组,但差异无统计学意义(P>0.05);实验组血栓形成最大振幅MA_(AA)(血凝块达到最大振幅)、MAADP(抗血小板治疗后缺血风险)、AA(血小板血栓素受体抑制剂对血小板的抑制百分比)、ADP(血小板A D P受体抑制剂等对血小板的抑制百分比)指标、凝血酶原时间(PT)、血小板计数(PLT)均优于对比组,差异有统计学意义(P<0.05);实验组纤维蛋白原(FIB)水平低于对比组,活化部分凝血活酶时间(APTT)短于对比组,差异有统计学意义(P<0.05)。结论:替格瑞洛在颅内动脉瘤支架辅助栓塞手术后氯吡格雷抵抗患者中的应用效果较好,值得临床应用。
Objective To observe the effect of Ticagrelor on the improvement of clopidogrel resistance in patients with intracranial aneurysms after stent assisted interventional surgery.Methods 104 patients with intracranial aneurysms in our hospital from January 2015 to December 2021 were randomLy divided into control group and experimental group.The control group was treated with Clopidogrel combined with Aspirin.The experimental group replaced Clopidogrel with Ticagrelor,and the therapeutic effects of the two groups were compared.Results The treatment effect of the experimental group was higher than the comparison group,and the incidence of adverse reactions was lower than the comparison group,(P>0.05);The MAAA(clot reaching the maximum amplitude),MAADP(ischemic risk after antiplatelet treatment),AA(percentage inhibition of platelet by thromboxane receptor inhibitor),ADP(percentage inhibition of platelet by platelet ADP receptor inhibitor,etc.)indexes of thrombosis maximum amplitude,PT(prothrombin time),PLT(platelet count),quality of life score and satisfaction score in the experimental group were higher than those in the control group,and the differences were statistically(P<0.05).The APTT,FIB,hospital stay and ambulation time of the experimental group were lower than those of the control group(both P<0.05).Conclusion Interventional surgery for intracranial aneurysms is widely used in clinical practice,and stent assisted therapy is more effective,and Ticagrelor intervention for patients with clopidogrel resistance is more effective,which deserves attention.
作者
陈晓
赵磊
许伟东
CHEN Xiao;ZHAO Lei;XU Weidong(Department of Neurosurgery,Rushan People’s Hospital,Weihai,Shandong 264500,China)
出处
《医药前沿》
2022年第29期1-3,7,共4页
Journal of Frontiers of Medicine
关键词
颅内动脉瘤
替格瑞洛
氯吡格雷抵抗
Intracranial aneurysm
Ticagrelor
Clopidogrel Resistance
