摘要
目的比较适形调强放疗同步紫杉醇脂质体与顺铂治疗局部晚期宫颈癌的疗效。方法选取乳山市人民医院2014年2月至2016年9月诊治的宫颈癌患者60例为研究对象,采用随机数字表法为对照组、观察组各30例。对照组行适形调强放疗同步顺铂治疗,观察组行适形调强放疗同步紫杉醇脂质体治疗,两组治疗5个周期。观察两组临床疗效及不良反应发生情况。结果观察组总有效率为93.3%(28/30),高于对照组的90.0%(27/30),但差异无统计学意义(P > 0.05)。观察组骨髓抑制、胃肠道反应发生率分别为26.7%(8/30)、53.3%(16/30),均低于对照组的46.7%(14/30)、76.7%(23/30),差异均有统计学意义(χ^(2)=5.16、7.17,均P < 0.05)。放化疗后,观察组生活质量评分均明显高于对照组(t=3.19、4.12、3.22、4.53、3.63、3.08、3.78,均P < 0.05)。结论适形调强放疗同步紫杉醇脂质体治疗局部晚期宫颈癌能够有效减少骨髓抑制和胃肠道反应的发生,改善患者的生活质量,在局部晚期宫颈癌患者的治疗中有一定临床意义。
Objective To investigate the efficacy of conformal intensity-modulated radiotherapy combined with paclitaxel liposome versus cisplatin in the treatment of locally advanced cervical cancer.Methods Sixty patients with cervical cancer who received treatment in Rushan People's Hospital from February 2014 to September 2016 were included in this study.They were randomly assigned to undergo either conformal intensity-modulated radiotherapy combined with cisplatin(control group,n=30)or conformal intensity-modulated radiotherapy combined with paclitaxel liposome(observation group,n=30)for five cycles.Clinical efficacy and incidence of adverse reactions were compared between the two groups.Results Total response rate in the observation group was slightly,but not significantly,higher than that in the control group[93.3%(28/30)vs.90.0%(27/30),P>0.05].The incidences of myelosuppression and gastrointestinal reactions in the observation group were 26.7%(8/30)and 53.3%(16/30),respectively,which were significantly lower than those in the control group[46.7%(14/30),76.7%(23/30),χ^(2)=5.16,7.17,both P<0.05].After radiotherapy and chemotherapy,the score of quality of life in the observation group was significantly higher than that in the control group(t=3.19,4.12,3.22,4.53,3.63,3.08,3.78,all P<0.05).Conclusion Conformal intensity-modulated radiotherapy combined with paclitaxel liposome for treatment of locally advanced cervical cancer can effectively reduce myelosuppression and gastrointestinal reactions and improve quality of life.Conformal intensity-modulated radiotherapy combined with paclitaxel liposome has certain clinical significance in the treatment of locally advanced cervical cancer.
作者
王利宁
杨美华
Wang Lining;Yang Meihua(Department of Oncology,Rushan People's Hospital,Rushan 264500,Shandong Province,China)
出处
《中国基层医药》
CAS
2022年第8期1141-1145,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
宫颈肿瘤
放射疗法
调强适形
抗肿瘤药
紫杉醇脂质体
顺铂
药物相关性副作用和不良反应
生活质量
疗效比较研究
Uterine cervical neoplasms
Radiotherapy,intensity-modulated
Antineoplastic agents
Liposomal paclitaxel
Cisplatin
Drug-related side effects and adverse reactions
Quality of life
Comparative effectiveness research
