摘要
目的研究CT评分及血清学指标联合预测颅脑损伤早期临床转归的价值。方法回顾性分析2019年1月至2021年12月江苏省无锡市第九人民医院及山西省阳煤集团总医院收治的118例颅脑损伤患者的临床资料,根据术后3个月的格拉斯哥预后量表扩展版评分将其分为预后良好组(76例)和预后不良组(42例)。比较两组临床资料、术前CT评分及血清白细胞介素(IL)-1β、IL-6、S100钙结合蛋白B(S100B)水平,并进一步分析颅脑损伤患者早期临床转归的影响因素及其对转归的预测价值。结果预后不良组入院格拉斯哥昏迷量表(GCS)评分3~8分占比、CT评分及血清IL-1β、IL-6、S100B水平均高于预后良好组,差异有统计学意义(P<0.05)。多因素分析结果显示,GCS评分3~8分、CT评分及血清IL-1β、IL-6、S100B水平是颅脑损伤患者早期预后不良的影响因素(P<0.05)。受试者操作特征曲线结果显示,CT评分及血清IL-1β、IL-6、S100B水平单独与联合对颅脑损伤患者早期预后不良均有一定的预测价值(曲线下面积>0.5,P<0.05)。结论CT评分与IL-1β、IL-6、S100B联合预测颅脑损伤患者的早期预后具有较高的价值。
Objective To study the value of CT score and serological indexs in predicting early clinical outcome of craniocerebral injury.Methods Clinical data of 118 patients with craniocerebral injury admitted to Wuxi Ninth People’s Hospital of Jiangsu Province and Yangquan Coal Industry(Group)General Hospital of Shanxi Province from January 2019 to December 2021 were retrospectively analyzed,and they were divided into good prognosis group(76 cases)and poor prognosis group(42 cases)according to the Glasgow outcome scale-extended score at three months after operation.The clinical data,preoperative CT scores,and serum levels of interleukin(IL)-1β,IL-6,and S100 calcium-binding protein B(S100B)were compared between the two groups,and the influencing factors of early clinical outcome in patients with craniocerebral injury and their predictive value for outcome were further analyzed.Results The proportion of Glasgow coma scale(GCS)score of 3-8 points,CT score,and serum levels of IL-1β,IL-6,and S100B in the poor prognosis group were higher than those in the good prognosis group,the differences were statistically significant(P<0.05).The results of multivariate analysis showed that GCS score of 3-8 points,CT score,and serum levels of IL-1β,IL-6,and S100B were the influential factors for early poor outcome of patients with craniocerebral injury(P<0.05).The results of the receiver operator characteristic curve showed that CT score and serum levels of IL-1β,IL-6,and S100B alone and in combination all had the value in predicting the early poor outcome of patients with craniocerebral injury(area under the curve>0.5,P<0.05).Conclusion CT score combines with IL-1β,IL-6,and S100B has high value in predicting early outcome of patients with craniocerebral injury。
作者
岳盛魁
刘浩波
潘东红
方伟
夏天
YUE Shengkui;LIU Haobo;PAN Donghong;FANG Wei;XIA Tian(Department of Neurosurgery,Wuxi Ninth People’s Hospital,Jiangsu Province,Wuxi214000,China;Department of Neurosurgery,Yangquan Coal Industry(Group)General Hospital,Shanxi Province,Yangquan045000,China)
出处
《中国医药导报》
CAS
2022年第35期70-73,共4页
China Medical Herald
基金
江苏省自然科学基金项目(BK20180126)。
关键词
颅脑损伤
临床转归
CT评分
血清学指标
联合预测
Craniocerebral injury
Clinical outcome
CT score
Serological index
Combined prediction
