摘要
目的通过分别检测并比较轻型颅脑损伤（m TBI）患者、格拉斯哥昏迷量表（GCS）评分在13~15分的中型颅脑损伤患者和健康对照组血清胶质细胞纤维酸性蛋白（GFAP）含量,为临床诊断m TBI患者提供依据。方法用ELISA法检测43例轻、35例中型颅脑损伤患者和20例健康对照组血清GFAP含量并采用ROC曲线分析,对比m TBI患者和中型颅脑损伤患者血清GFAP含量与头颅CT的关系。结果血清GFAP含量对鉴别m TBI患者和健康人群有一定准确性（AUC=0.726）;对鉴别GCS评分在13~15分的中型颅脑损伤患者和健康人群有较高准确性（AUC=0.914）;血清GFAP含量对鉴别头颅CT阳性和阴性患者有一定准确性（AUC=0.762）。结论血清GFAP可作为m TBI患者诊断的生物标志物,对鉴别颅脑损伤后头颅CT阳性和阴性患者有一定准确性,可以为减少m TBI患者头颅CT检查提供依据。
Objective To provide basis for diagnosis the patients with mild traumatic brain injury（ m TBI） by detecting and comparing separately the contents of the serum glial fibrillary acidic protein（ GFAP） among patients with（ m TBI）,the patients with moderate traumatic brain injury whose glasgow coma scale（ GCS） score is 13- 15 points and healthy control group. Methods Detected serum GFAP content by ELISA in 43 cases of patients with m TBI,35 cases of patients with moderate traumatic brain injury whose GCS score is 13- 15 points and 20 healthy subjects,then using ROC curve analysis the results. Results There is a certain accuracy（ AUC = 0. 726） that serum GFAP content may distinguish between the patients with m TBI and healthy people,high accuracy（ AUC = 0. 914） in distinguish between the patients with patients with moderate traumatic brain injury and healthy people. It has a certain accuracy（ AUC = 0. 762） that serum GFAP content can distinguish between patients with positive and negative head CT. Conclusion The content of serum GFAP can be used as a biomarker in diagnose the patients with m TBI. It has a certain accuracy that can distinguish between patients with positive and negative head CT,and can reduce the examination of head CT in patients with m TBI.
出处
《临床神经外科杂志》
CAS
2016年第2期127-130,共4页
Journal of Clinical Neurosurgery
基金
同济大学附属杨浦医院院级科研基金项目(Se1201410)
