摘要
目的:探讨降钙素原(procalcitonin,PCT)、C反应蛋白(C reactive protein,CRP)及CD4^(+)T淋巴细胞水平在人类免疫缺陷病毒(HIV)感染患者结核分枝杆菌(Mycobaterium tuberculosis,MT)感染早期诊断中的应用价值。方法:选取2021年1月—2024年5月常州市第三人民医院收治的69例HIV感染患者为研究对象,根据是否合并MT感染分为单纯HIV感染组(n=35)和HIV合并MT感染组(n=34)。检测两组患者的PCT、CRP及CD4^(+)T淋巴细胞水平,比较两组以上指标的差异,并对HIV合并MT感染患者的以上指标进行相关性分析。通过受试者操作特征(ROC)曲线评估PCT、CRP及CD4^(+)T淋巴细胞水平在MT感染早期诊断中的效能。结果:HIV合并MT感染组的PCT、CRP水平均显著高于单纯HIV感染组,CD4^(+)T淋巴细胞水平显著低于单纯HIV感染组,差异均有统计学意义(P<0.05)。HIV合并MT感染患者中,PCT与CRP水平呈显著正相关(rs=0.607,P<0.001),CD4^(+)T淋巴细胞水平与PCT、CRP均呈负相关(rs=-0.751、-0.700,P<0.001)。ROC曲线分析显示,PCT、CRP及CD4^(+)T淋巴细胞联合检测MT感染的曲线下面积(AUC)为0.911,特异度为97.1%,均显著高于单独检测。结论:PCT、CRP及CD4^(+)T淋巴细胞水平的联合检测在HIV患者MT感染的早期诊断中有较高价值。
Objective:To investigate the application value of procalcitonin(PCT),C reactive protein(CRP)and CD4^(+)T lymphocyte in early diagnosis of Mycobaterium tuberculosis(MT)infection in patients with human immunodeficiency virus(HIV)infection.Method:A total of 69 patients with HIV infection admitted to the Third People's Hospital of Changzhou from January 2021 to May 2024 were selected as the study objects.They were divided into simple HIV infection group(n=35)and HIV combined with TB infection group(n=34)according to whether they were infected with MT.The PCT,CRP and CD4^(+)T lymphocyte levels of patients in the two groups were detected,and the differences of the above indexes between the two groups were compared,and the correlation analysis were conducted for the above indexes of patients with HIV combined with TB infection.The efficacy of PCT,CRP and CD4^(+)T lymphocyte levels in the early diagnosis of MT were evaluated by receiver operating characteristic(ROC)curve.Result:The levels of PCT and CRP in HIV combined with TB infection group were significantly higher than those in simple HIV infection group,and the level of CD4^(+)T lymphocytes was significantly lower than that in simple HIV infection group,the differences were statistically significant(P<0.05).In patients with HIV combined with TB infection,PCT and CRP levels were positively correlated(rs=0.607,P<0.001),and CD4^(+)T lymphocyte levels were negatively correlated with PCT and CRP levels(rs=-0.751,-0.700,P<0.001).ROC curve analysis showed that the area under the curve(AUC)of PCT,CRP and CD4^(+)T lymphocytes combined detection of MT infection was 0.911,and the specificity was 97.1%,which were significantly higher than those of single detection.Conclusion:The combined detection of PCT,CRP and CD4^(+)T lymphocyte levels is of high value in the early diagnosis of MT infection in patients with HIV infection.
作者
马波
卫峥
陈国春
MA Bo;WEI Zheng;CHEN Guochun(Department of Infectious Diseases,the Third People's Hospital of Changzhou,Changzhou 213001,China;不详)
出处
《中国医学创新》
CAS
2024年第36期116-120,共5页
Medical Innovation of China
