摘要
目的 分析窄谱光(DPL)联合羟氯喹治疗玫瑰痤疮的疗效及炎症损害和对生活质量的影响。方法 选取60例玫瑰痤疮患者,按照治疗方案不同将患者分为对比组和研究组,每组30例。对比组给予羟氯喹治疗,研究组给予DPL联合羟氯喹治疗。比较两组临床疗效、不良反应发生情况、皮损症状改善、生活质量和炎症因子水平。结果 研究组临床总有效率96.67%明显高于对比组的80.00%,差异有统计学意义(P<0.05)。研究组红肿、紫癜及皮肤干燥紧绷不良反应发生率13.33%与对比组的10.00%比较差异无统计学意义(P>0.05)。治疗后,两组毛细血管扩张、面部红斑、脓包丘疹及瘙痒评分均低于本组治疗前,且研究组毛细血管扩张评分为(0.84±0.19)分、面部红斑评分为(0.82±0.18)分、脓包丘疹评分为(0.88±0.19)分、瘙痒评分为(0.85±0.18)分,均低于对比组的(1.12±0.22)、(1.06±0.21)、(1.03±0.25)、(1.11±0.22)分,差异有统计学意义(P<0.05)。治疗4、8、12周,研究组皮肤病生活质量量表(DLQI)评分分别为(18.35±2.36)、(12.01±1.75)、(8.16±1.17)分,均低于对比组的(20.88±3.25)、(14.92±2.67)、(10.63±1.62)分,差异有统计学意义(P<0.05)。治疗后,两组白介素-1α(IL-1α)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均低于本组治疗前,且研究组IL-1α水平为(31.47±8.55)pg/ml、IL-6水平为(32.43±8.67)pg/ml、IL-8水平为(15.45±4.06)pg/ml、TNF-α水平为(20.05±3.66)pg/ml,均低于对比组的(45.32±10.24)、(44.06±10.45)、(26.79±6.32)、(28.47±4.49)pg/ml,差异有统计学意义(P<0.05)。结论 对玫瑰痤疮患者采用DPL联合羟氯喹治疗可取得显著的临床效果,不良反应发生率低,且能更好地改善患者皮损症状、生活质量及炎症因子水平,值得临床推广。
Objective To analyze the efficacy inflammation of dye pulse light(DPL) combined with hydroxychloroquine in the treatment of acne rosacea, and its influence on quality of life. Methods A total of 60 patients with acne rosacea were divided into a comparison group and a research group according to different treatment regimens, with 30 patients in each group. The comparison group was treated with hydroxychloroquine,and the research group was treated with DPL combined with hydroxychloroquine. The clinical efficacy, occurrence of adverse reactions, improvement of skin lesions symptoms, quality of life and levels of inflammatory factors were compared between the two groups. Results The total clinical effective rate of the research group was 96.67%, which was higher than 80.00% of the comparison group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions such as redness, purpura and skin dryness and tightness in the research group was 13.33%, which was no statistically significant compared with 10.00% in the comparison group(P>0.05). After treatment, the scores of telangiectasia, facial erythema, abscess papule and pruritus in both groups were lower than those before treatment in this group;the scores of telangiectasia, facial erythema,abscess papule and pruritus in the research group were(0.84±0.19),(0.82±0.18),(0.88±0.19) and(0.85±0.18) points, which were lower than(1.12±0.22),(1.06±0.21),(1.03±0.25) and(1.11±0.22) points in the comparison group;the differences were statistically significant(P<0.05). At 4, 8, and 12 weeks of treatment,the dermatology life quality index(DLQI) scores in the research group were(18.35±2.36),(12.01±1.75), and(8.16±1.17), points, which were lower than(20.88±3.25),(14.92±2.67), and(10.63±1.62) points in the comparison group, and the differences were statistically significant(P<0.05). After treatment, the interleukin-1 α(IL-1α), interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) in the two groups were lower than th
作者
严松华
YAN Song-hua(Huaian Fifth People's Hospital,Huaian 223300,China)
出处
《中国实用医药》
2022年第27期152-155,共4页
China Practical Medicine
关键词
玫瑰痤疮
羟氯喹
窄谱光
炎症水平
不良反应
生活质量
Acne rosacea
Hydroxychloroquine
Dye pulse light
Inflammation level
Adverse reactions
Quality of life
