摘要
目的 观察玻璃酸钠注射液联合针刀松解术对膝骨关节炎患者关节功能及血清超氧化物歧化酶(SOD)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)表达的影响。方法 将我院90例膝骨性关节炎(KOA)患者随机分为针刀组与联合组各45例。针刀组应用针刀松解术治疗,联合组在针刀松解术的基础上联合关节腔内注射玻璃酸钠注射液。观察两组临床疗效,评估两组患者治疗前后膝关节功能[膝关节损伤及骨性关节炎转归评分(KOOS)]、血清SOD、NO、TNF-α水平以及患者疼痛和焦虑状况[数字评分法(NRS)、焦虑视觉模拟量表(VAS-A)]。结果 治疗后,联合组临床总有效率高于针刀组(P<0.05);两组患者KOOS评分均较治疗前升高(P<0.05),联合组KOOS评分升高更显著(P<0.05);两组患者血清SOD水平升高,NO、TNF-α水平降低(P<0.05),联合组上述指标改善更显著(P<0.05);联合组NRS、VAS-A评分均明显低于针刀组(P<0.05)。结论 玻璃酸钠注射液联合针刀松解术治疗KOA效果显著,能有效缓解患者疼痛症状、改善其膝关节功能,并调节SOD、NO、TNF-α水平。
Objective To observe the effects of sodium hyaluronate(SH)injection combined with acupotomy on joint function,serum superoxide dismutase(SOD),nitric oxide(NO)and tumor necrosis factor-α(TNF-α)in patients with knee osteoarthritis(KOA). Methods Ninety KOA patients were randomly divided into acupotomy group(acupotomy) and combination group(acupotomy combined with intra-articular SH injection),45 cases in each group. The clinical curative effect was observed. The knee function [Knee injury and osteoarthritis outcome score(KOOS)],levels of serum SOD,NO and TNF-α,pain and anxiety status [Numeric rating scale(NRS),Visual analogue scale for anxiety(VAS-A)] before and after treatment in both groups were evaluated. Results After treatment,the clinical response rate of combination group was higher than that of acupotomy group(P <0.05);KOOS scores were increased in both groups( P<0.05),which were higher in combination group than in acupotomy group( P<0.05);serum SOD level was increased,while NO and TNF-α levels were decreased in both groups ( P<0.05),and the improvement of the above indexes in combination group was more significant than in acupotomy group( P<0.05);NRS and VAS-A scores in combination group were significantly lower than those in acupotomy group( P<0.05).Conclusion The curative effect of SH injection combined with acupotomy is significant on KOA,which can effectively relieve pain symptoms of patients,improve knee function,and regulate SOD,NO and TNF-α levels.
作者
邹梦颖
黄诚
谭德慧
武晓寒
郭长青
ZOU Meng-ying;HUANG Cheng;TAN De-hui;WU Xiao-han;GUO Chang-qing(Department of TCM,Specialized Medical Center of Rocket Force,Beijing 100088;The Second Department of Massage,Beijing Massage Hospital,Beijing 100035;School of Acupuncture and Massage,Beijing University of Chinese Medicine,Beijing 100029)
出处
《湖北中医药大学学报》
2022年第5期36-39,共4页
Journal of Hubei University of Chinese Medicine
基金
国家自然科学基金面上项目(项目编号:81574067)。
