摘要
目的探讨膝骨关节炎(KOA)给予玻璃酸钠+非甾体抗炎药治疗的效果。方法200例KOA患者,随机分为观察组和对照组,各100例。观察组采用玻璃酸钠+非甾体抗炎药治疗,对照组采用玻璃酸钠治疗。对比两组患者炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平、骨关节炎指数(WOMAC)、膝关节功能评分[膝关节功能评价表(Lysholm)]、膝关节损伤与骨关节炎结果评分(KOOS评分)。结果治疗后,观察组TNF-α(6.1±0.7)pg/ml、IL-6(2.2±0.2)ng/L、CRP(10.3±3.0)mg/L低于对照组的(7.3±1.0)pg/ml、(3.1±0.8)ng/L、(13.0±3.2)mg/L(P<0.05)。治疗后,观察组疼痛、僵硬、关节功能评分分别为(15.3±1.7)、(5.5±0.7)、(36.7±5.6)分,均较对照组的(21.3±2.1)、(8.0±1.0)、(60.3±7.8)分更低(P<0.05)。治疗后,观察组跛行、楼梯攀爬、下蹲、使用支撑物、疼痛、不稳定感、交锁感、肿胀度评分分别为(4.5±0.6)、(9.2±1.0)、(4.4±0.4)、(4.3±0.4)、(24.6±3.2)、(24.0±2.8)、(7.6±1.1)、(9.1±0.9)分,均较对照组的(3.1±0.4)、(7.2±0.8)、(3.1±0.3)、(3.1±0.3)、(20.6±2.8)、(20.7±2.6)、(3.3±1.5)、(7.6±0.8)分更高(P<0.05)。治疗后,观察组膝关节相关的生活质量、运动及娱乐能力、日常生活活动、症状、疼痛评分分别为(10.8±1.8)、(12.6±2.9)、(55.9±3.7)、(20.8±3.5)、(23.4±2.1)分,均较对照组的(8.8±1.6)、(9.7±2.4)、(49.2±4.5)、(15.1±3.2)、(19.5±2.7)分更高(P<0.05)。结论玻璃酸钠与非甾体抗炎药联合治疗KOA可有效改善患者的膝关节功能,价值较高。
Objective To investigate the therapeutic effect of sodium hyaluronate+Nonsteroidal anti-inflammatory drug on knee osteoarthritis(KOA).Methods 200 patients with KOA were randomly divided into the observation group and the control group,each with 100 cases.The observation was treated with sodium hyaluronate+nonsteroidal anti-inflammatory drug,and the control group was treated with sodium hyaluronate.Both groups were compared in terms of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)]levels,Western Ontario and McMaster University(WOMAC),knee joint function score(Lysholm score),knee injury and osteoarthritis outcome score(KOOS score).Results After treatment,the observation group had TNF-αof(6.1±0.7)pg/ml,IL-6 of(2.2±0.2)ng/L and CRP of(10.3±3.0)mg/L,which were lower than(7.3±1.0)pg/ml,(3.1±0.8)ng/L and(13.0±3.2)mg/L in the control group(P<0.05).After treatment,the scores of pain,stiffness and joint function in the observation group were(15.3±1.7),(5.5±0.7)and(36.7±5.6)points,which were lower than(21.3±2.1),(8.0±1.0)and(60.3±7.8)points in the control group(P<0.05).After treatment,the scores of lameness,stair climbing,squatting,use of support,pain,instability,interlocking and swelling in the observation group were(4.5±0.6),(9.2±1.0),(4.4±0.4),(4.3±0.4),(24.6±3.2),(24.0±2.8),(7.6±1.1)and(9.1±0.9)points,which were higher than(3.1±0.4),(7.2±0.8),(3.1±0.3),(3.1±0.3),(20.6±2.8),(20.7±2.6),(3.3±1.5)and(7.6±0.8)points in the control group(P<0.05).After treatment,the scores of knee joint related quality of life,exercise and recreation capacity,activities of daily living,symptoms,and pain in the observation group were(10.8±1.8),(12.6±2.9),(55.9±3.7),(20.8±3.5)and(23.4±2.1)points,which were higher than(8.8±1.6),(9.7±2.4),(49.2±4.5),(15.1±3.2)and(19.5±2.7)points in the control group(P<0.05).Conclusion Sodium hyaluronate combined with nonsteroidal anti-inflammatory drug can effectively improve the knee joint function of patients with KOA,with
作者
徐雅芳
XU Ya-fang(The First People's Hospital of Zhenjiang City,Zhenjiang 212009,China)
出处
《中国现代药物应用》
2024年第3期111-114,共4页
Chinese Journal of Modern Drug Application
关键词
膝骨关节炎
玻璃酸钠
非甾体抗炎药
膝关节功能
炎症因子
Knee osteoarthritis
Sodium hyaluronate
Nonsteroidal anti-inflammatory drug
Knee joint function
Inflammatory factors
