摘要
目的 观察妊娠期糖尿病(Gestational diabetes mellitus,GDM)患者使用门冬胰岛素联合二甲双胍药物,对其血糖及妊娠结局的影响。方法 选择经本院收治的GDM患者选取110例开展研究,按照同等比例将患者分为对照组55例和观察组55例,其中对照组予以门冬胰岛素治疗,观察者在对照基础上联合二甲双胍药物进行治疗,对比治疗后两组患者血糖水平变化和孕妇妊娠结局情况,对比两组新生儿并发症情况。结果 治疗后观察组患者FPG(4.26±0.67)mmol/L、1hPG(8.11±0.23)mmol/L、2hPG(7.41±0.38)mmol/L水平数值均低于对照组(5.12±0.87)mmol/L、(8.46±0.13)mmol/L、(7.72±0.11)mmol/L,差异有统计学意义(P<0.05);观察组妊娠结局优于对照组,观察组患者剖宫产、羊水过多、巨大儿并发症总发生率12.72%,低于对照组30.91%,差异有统计学意义(P<0.05);对比2组新生儿并发症发生情况,观察组10.91%,低于对照组27.27%,差异有统计学意义(P<0.05)。结论 采用门冬胰岛素联合二甲双胍药物治疗GDM,可使其血糖得以降低、两者联合用药治疗效果更好,使患者血糖控制在正常范围,使得妊娠结局得以改善、并发症得以减少,可进行推广应用。
Objective To observe the effect of insulin aspart combined with metformin on blood glucose and pregnancy out come in patients with gestational diabetes mellitus(GDM).Methods 110 GDM patients admitted to our hospital were selected to carry out research,and the patients were divided into control group(55 cases) and observation group(55 cases)according to the same proportion.The observers were treated with metformin on the basis of control.The changes of blood glucose level and pregnancy outcome of pregnant women in the two groups were compared,and the neonatal complications were compared between the two groups.Results After treatment,the levels of FPG(4.26 0.67)mmol/L,1HPG(8.11 0.23)mmol/L and 2HPG(7.41 0.38)mmol/L in the observation group were lower than those in the control group(5.12 0.87)mmol/L and(8.46)The pregnancy outcome in the observation group was better than that in the control group.The total incidence of cesarean section,polyhydramnios and macrosomia in the observation group was 12.72%,which was lower than that in the control group(30.91%,P<0.05).The incidence of neonatal complications in the observation group was 10.91%,which was lower than that in the control group(27.27%,P<0.05).Conclusion Insulin aspart combined with metformin is used to treat GDM,It can reduce the blood sugar,and the combination of the two drugs has better therapeutic effect,so that the blood sugar of patients can be controlled in the normal range,and the pregnancy outcome can be improved and the complications can be reduced,which can be popularized and applied.
作者
范丽君
田莉
石学敏
Fan Lijun;Tian Li;Shi Xuemin(Department of Obstetrics and Gynecology,Anyang Maternal and Child Health Hospital,Anyang 455000,China)
出处
《哈尔滨医药》
2022年第5期42-43,共2页
Harbin Medical Journal
