摘要
目的 探讨在妊娠期糖尿病孕妇的治疗中采取二甲双胍联合门冬胰岛素的临床效果,对孕妇血糖控制以及妊娠结局的影响。方法 回顾性分析2021年4月—2023年4月青海省妇女儿童医院收治的80例妊娠期糖尿病孕妇的临床资料,按治疗方式分为对照组(n=40,门冬胰岛素治疗)与研究组(n=40,二甲双胍联合门冬胰岛素治疗),对比两组血糖水平、血糖恢复正常时间及胰岛素用量、炎性因子水平、母婴结局。结果 研究组空腹血糖、餐后2 h血糖、糖化血红蛋白均较对照组低,差异有统计学意义(P均<0.05);研究组空腹血糖、餐后2 h血糖恢复正常时间及胰岛素用量较对照组少,差异有统计学意义(P均<0.05);研究组白细胞介素-6、肿瘤坏死因子-α水平均较对照组低,差异有统计学意义(P均<0.05);研究组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论 在妊娠期糖尿病的治疗中服用二甲双胍治疗的同时配合注射门冬胰岛素效果显著,可有效控制血糖并改善妊娠结局。
Objective To explore the clinical effect of metformin combined with insulin aspart in the treatment of preg-nant women with gestational diabetes,and the effects of the blood glucose control and pregnancy outcomes of pregnant women.Methods The clinical date of 80 pregnant women with gestational diabetes admitted to Qinghai Provincial Women and Children's Hospital from April 2021 to April 2023 were retrospectively analyzed.According to different treatment they were divided into control group(n=40,treated with insulin aspart)and the study group(n=40,treated with metformin combined with insulin aspart).Compared blood glucose levels,time for blood glucose to return to nor-mal,insulin dosage,the level of inflammatory factors,and maternal and infant outcomes between the two groups.Results The fasting blood glucose,2-hour postprandial blood glucose,and glycosylated hemoglobin in the study group were all lower than those in the control group,and the differences were statistically significant(all P<0.05).The time for fasting blood glucose and 2-hour postprandial blood glucose to return to normal,and the amount of insulin in the study group were less than those in the control group,and the differences were statistically significant(all P<0.05).In-terleukin-6 and tumor necrosis factor-αin the study group were lower than those in the control group,and the differ-ences were statistically significant(both P<0.05).The incidence of adverse pregnancy outcomes in the study group was lower than that in the control group and the difference was statistically significant(P<0.05).Conclusion In the treatment of gestational diabetes,taking metformin and injecting insulin aspart has a significant effect,which can ef-fectively control blood glucose and improve pregnancy outcomes.
作者
张喜梅
ZHANG Ximei(Department of Obstetrics and Gynecology,Qinghai Provincial Women and Children's Hospital,Xining,Qinghai Province,810008 China)
出处
《糖尿病新世界》
2024年第2期116-118,126,共4页
Diabetes New World Magazine
关键词
二甲双胍
门冬胰岛素
血糖水平
妊娠结局
Metformin
Insulin aspart
Blood glucose level
Pregnancy outcome
