摘要
目的探讨缺血性卒中伴卵圆孔未闭(PFO)患者炎性反应标志物及影像学特征。方法回顾性连续纳入2018年4月至2022年6月在武汉大学中南医院神经内科住院的71例急性缺血性卒中伴PFO患者(伴PFO组),并纳入同期年龄、性别相匹配的不伴PFO的缺血性卒中住院患者71例作为对照(不伴PFO组)。经颅多普勒超声发泡试验存在右向左分流即诊断为PFO,并经食道超声检查证实。比较两组患者基线资料[年龄、性别及吸烟、饮酒、高血压病、糖尿病、高脂血症、高尿酸血症史和心脏病(心房颤动、冠心病)史]、常规实验室指标(血红蛋白、血小板计数、空腹血糖、总胆固醇、高密度脂蛋白、低密度脂蛋白、谷草转氨酶、谷丙转氨酶、白蛋白、血肌酐、纤维蛋白原、凝血酶时间)、炎性反应标志物[淋巴细胞计数、全身炎症反应指数(SIRI)、纤维蛋白原与白蛋白的比值(FAR)、白细胞计数、中性粒细胞计数、单核细胞计数]、影像学特征[梗死类型(单发、多发)、横径(<1.5 cm或≥1.5 cm)、是否为后循环]的差异。结果(1)两组患者年龄、性别及吸烟、饮酒、高血压病、糖尿病、高脂血症、高尿酸血症史和心脏病史的组间差异均无统计学意义(均P>0.05)。(2)两组患者血红蛋白、血小板计数、空腹血糖、总胆固醇、高密度脂蛋白、低密度脂蛋白、谷草转氨酶、谷丙转氨酶、白蛋白、血肌酐、纤维蛋白原、凝血酶时间的差异均无统计学意义(均P>0.05)。(3)缺血性卒中伴PFO组淋巴细胞计数低于缺血性卒中不伴PFO组[1.60(1.24,2.20)×10^(9)/L比1.90(1.58,2.30)×10^(9)/L,Z=-2.087],SIRI高于缺血性卒中不伴PFO组[1.35(0.94,1.88)比1.10(0.73,1.53),Z=2.276],差异均有统计学意义(均P<0.05);两组白细胞计数、中性粒细胞计数、单核细胞计数、FAR的组间差异均无统计学意义(均P>0.05)。(4)缺血性卒中伴PFO组梗死灶以多发为主,其占比高于�
Objective To investigate the inflammatory markers and imaging features of patients with ischemic stroke and patent foramen ovale(PFO).Methods From April 2018 to June 2022,71 patients with acute ischemic stroke and PFO(PFO group)admitted to Department of Neurology,Zhongnan Hospital of Wuhan University were selected retrospectively,while 71 patients with ischemic stroke without PFO and matched the same age and gender as control group(non-PFO group).Baseline data(age,sex,smoking history,drinking history,hypertension,diabetes,hyperlipidemia,hyperuricemia and heart disease[atrial fibrillation,coronary heart disease]),routine biochemical indicators(hemoglobin,platelet count,fasting blood glucose,total cholesterol,high-density lipoprotein,low-density lipoprotein,aspartate aminotransferase,alanine aminotransferase,albumin,creatinine,fibrinogen,thrombin time),inflammatory markers(lymphocyte count,systemic inflammatory response index[SIRI],fibrinogen to albumin ratio[FAR],white blood cell count,neutrophil count,monocyte count),imaging features(infarction type[single or multiple],transverse diameter[<1.5 cm or≥1.5 cm],posterior circulation infarction or not)were compared between the two groups.Results(1)There was no significant difference between the two groups in age,sex,smoking history,drinking history,hypertension,diabetes,hyperlipidemia,hyperuricemia and heart disease(all P>0.05).(2)There was also no significant difference in hemoglobin platelet count,fasting blood glucose,total cholesterol,high-density lipoprotein,low-density lipoprotein,aspartate aminotransferase,alanine aminotransferase,albumin,creatinine,fibrinogen,and thrombin time between the two groups(all P>0.05).(3)The PFO group has lower lymphocyte count(1.60[1.24,2.20]×10^(9)/L vs.1.90[1.58,2.30]×10^(9),Z=-2.087),higher SIRI(1.35[0.94,1.88]vs.1.10[0.73,1.53],Z=2.276)than the non-PFO group,with significant differences(all P<0.05).There was no distinct difference between the two groups in terms of white blood cell count,neutrophil count,monocyte count and F
作者
胡营营
赵文艳
周玉亮
徐志鹏
Hu Yingying;Zhao Wenyan;Zhou Yuliang;Xu Zhipeng(Department of Neurology,Zhongnan Hospital of Wuhan University,Wuhan 430062,China)
出处
《中国脑血管病杂志》
CAS
CSCD
北大核心
2022年第11期756-762,共7页
Chinese Journal of Cerebrovascular Diseases
基金
湖北省重点研发计划(2022BCA039)。
